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[Clinical practice guidelines for the diagnosis and treatment of anemia of prematurity (2025)].
Zhongguo Dang Dai Er Ke Za Zhi
January 2025
Anemia of prematurity (AOP) is a multifactorial condition associated with congenital iron deficiency, low erythropoietin levels, a short lifespan of red blood cells, and iatrogenic blood loss. AOP is a common complication in premature infants that can adversely affect growth, development, and long-term neurocognitive outcomes. To standardize the diagnosis and treatment of AOP, the Neonatal Clinical Practice Guidelines Expert Committee and the Neonatal Evidence-Based Medicine Group of the Commission of Neonatal Medicine of the Cross-Strait Medical and Health Exchange Association, along with the Editorial Office of the , have developed the "Clinical practice guidelines for the diagnosis and treatment of anemia of prematurity (2025)", based on the World Health Organization's handbook for guideline development and the formulation/revision principles of Chinese clinical practice guidelines.
View Article and Find Full Text PDFMilitary influences on the evolution of clinical trials throughout history.
Clin Trials
January 2025
Department of Urology, University of Rochester Medical Center, Rochester, NY, USA.
Clinical trials of drugs, procedures, and other therapies play a crucial role in advancing medical science by evaluating the safety, efficacy, and optimal use of medical interventions. The design and implementation of these trials have evolved significantly over time, reflecting advancements in medicine, ethics, and methodology. Early historical examples, such as King Nebuchadnezzar II's and his captives' dietary experiment and Ambroise Paré's treatment of gunshot wounds, laid some foundational principles of trial design.
View Article and Find Full Text PDFIL-17 triggers PD-L1 gene transcription in NSCLC cells via TRIM31-dependent MEF2C K63-linked polyubiquitination.
BMC Cancer
January 2025
Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China.
Background: Non-small cell lung cancer (NSCLC) is a disease related to inflammation. Proinflammatory cytokines such as interleukin 17 (IL-17) can induce cancer cell proliferation, metastasis and immune escape. Although NSCLC immune escape is partly due to the interaction between PD-1 and PD-L1 and PD-L1 expression can be upregulated in cancer cells upon stimulation with IL-17, the underlying mechanism of IL-17-triggered PD-L1 gene transcription in NSCLC cells remains elusive.
View Article and Find Full Text PDF3D Bioprinted Head and Neck Squamous Cell Carcinoma (HNSCC) Model Using Tunicate Derived Nanocellulose (NC) Bioink.
Adv Healthc Mater
January 2025
Institute of Transfusion Medicine and Immunology, Medical Faculty Mannheim, Heidelberg University, German Red Cross Blood Donor Service Baden-Württemberg - Hessen, 68167, Mannheim, Germany.
Head and neck squamous cell carcinoma (HNSCC) are invasive solid tumors accounting for high mortality. To improve the clinical outcome, a better understanding of the tumor and its microenvironment (TME) is crucial. Three -dimensional (3D) bioprinting is emerging as a powerful tool for recreating the TME in vitro.
View Article and Find Full Text PDFClinical depression prevalence and associated factors among adolescents with sickle cell anemia in dar es salaam, tanzania: a cross-sectional study.
BMC Pediatr
January 2025
The Sickle Pan-African Research Consortium (SPARCO) - Tanzania, Muhimbili University of Health and Allied Sciences, Dar Es Salaam, Tanzania.
Background: Depression commonly arises among adolescents who have experienced long-standing psychosocial difficulties, especially those facing chronic illnesses such as sickle cell anemia (SCA). SCA is a global health concern, and Tanzania is one of the countries with a high incidence, estimated at 8,000-11,000 births per year. This study aims to assess the magnitude and factors associated with depression among adolescents with SCA.
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