AI Article Synopsis
- To understand nanoparticles' interactions and ensure their integrity, studying their pharmacokinetic profiles is essential.
- Various tracking methods have been used to evaluate nanoparticles' fate and structural integrity, but they offer different levels of information, which can lead to misinterpretations.
- Förster resonance energy transfer (FRET) shows great promise for tracking nanoparticles, yet it still needs validated methods for quantifying and extracting nanoparticles from biological fluids and tissues.
Article Abstract
To understand how nanoparticles (NPs) interact with biological barriers and to ensure they maintain their integrity over time, it is crucial to study their pharmacokinetic (PK) profiles. Many methods of tracking have been used to describe the fate of NPs and to evaluate their PKs and structural integrity. However, they do not deliver the same level of information and this may cause misinterpretations. Here, the authors review and discuss the different methods for tracking of organic NPs. Among them, Förster resonance energy transfer (FRET) presents great potential to track NPs' integrity. However, FRET still requires validated methods to extract and quantify NPs in biological fluids and tissues.
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| http://dx.doi.org/10.2217/nnm-2021-0155 | DOI Listing |
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