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Predicting few disinfection byproducts in the water distribution systems using machine learning models.
Environ Sci Pollut Res Int
January 2025
Research Engineer I, Applied Research Center for Environment & Marine Studies, Research Institute, King Fahd University of Petroleum & Minerals, 31261, Dhahran, Saudi Arabia.
Concerns regarding disinfection byproducts (DBPs) in drinking water persist, with measurements in water treatment plants (WTPs) being relatively easier than those in water distribution systems (WDSs) due to accessibility challenges, especially during adverse weather conditions. Machine learning (ML) models offer improved predictions of DBPs in WDSs. This study developed multiple ML models to predict Trihalomethanes (THMs), Haloacetic Acids (HAAs), Dichloroacetonitrile (DCAN), and N-nitrosodimethylamine (NDMA) in WDSs using data collected over 13 years (2008-2020) from 113 water supply systems (WSS) in Ontario.
View Article and Find Full Text PDFHighly sensitive and robust LC-MS/MS method for determination of up to 15 small molecule nitrosamine impurities in pharmaceutical drug substances.
J Pharm Sci
November 2024
United States Pharmacopeia India Pvt Ltd, Hyderabad, Telangana, India.
Nitrosamine impurities have been classified as probable human carcinogens for decades. These impurities were reported in water, food, tobacco, pesticides, and plastics but received attention in mid-2018 when N-nitrosodimethylamine (NDMA) was reported in valsartan drug products. Subsequently, it was revealed that several small molecule and complex nitrosamine impurities can form in any active pharmaceutical ingredient (API) or drug product in which secondary or tertiary amines are present (as API or as impurities) along with a nitrosating agent.
View Article and Find Full Text PDFThe association between N-nitrosamines exposure and lipid metabolism in the high incidence area of esophageal cancer: A case-control analysis.
Environ Pollut
December 2024
Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, 210009, People's Republic of China. Electronic address:
Environmental carcinogens such as N-nitrosamines are high-risk factors for the development of esophageal cancer (EC). However, the association between nitrosamines exposure and lipid metabolism disorders in human EC remained largely obscure. Therefore, we conducted a population-based case-control study established with esophageal inflammation (BCH), esophageal heterotrophic hyperplasia (DYS), patients with primary EC and matched controls in high prevalence area of EC in China.
View Article and Find Full Text PDFNDMA enhances claudin-1 and -6 expression viaCYP2E1/ROS in AGS cells.
Toxicol In Vitro
January 2025
Laboratorio de Inmunobiología, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM, Mexico. Electronic address:
Carcinogenic N-nitroso compounds, especially N-nitroso dimethylamine, increase the risk of gastric cancer development. Cytochrome P450-2E1 metabolizes this compound, thus generating an oxidant microenvironment. We aimed to evaluate in gastric adenocarcinoma cells if its effect on CYP2E1 and ROS affects signaling pathways associated with gastric cancer oncogenesis.
View Article and Find Full Text PDFPBPK model-based gender-specific risk assessment of N-nitrosodimethylamine (NDMA) using human biomonitoring data.
Arch Toxicol
October 2024
College of Pharmacy, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea.
Article Synopsis
- The study assesses human exposure to NDMA by comparing biomonitoring measurements in healthy Korean men and women to gender-specific exposure guidance values.
- A physiologically based pharmacokinetic (PBPK) model was developed, incorporating physiological and biochemical parameters, to better understand how NDMA is processed in the body.
- Findings revealed that daily exposures to NDMA are approximately 3.95 μg/day/kg for men and 10.60 μg/day/kg for women, providing essential data for future risk management and regulatory decisions.
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