Detecting using a nitrofuranyl calanolide-trehalose probe based on nitroreductase Rv2466c.

Chem Commun (Camb)

School of Pharmaceutical Sciences, Tsinghua University, Haidian Dist., Beijing 100084, P. R. China.

Published: December 2021

A new Mtb fluorescent probe, NFC-Tre-5, was reported that could label single cells of Mtb under various stress conditions a unique fluorescence off-on feature by a Rv2466c-mediated reductive mechanism. This probe effectively facilitates the rapid and specific detection of Mtb in the host cell during infection and the detection of Mtb in sputum samples from patients.

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Source
http://dx.doi.org/10.1039/d1cc05187cDOI Listing

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