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Reversing tumor multidrug resistance with a catalytically active covalent organic framework. | LitMetric

Reversing tumor multidrug resistance with a catalytically active covalent organic framework.

Chem Commun (Camb)

College of Chemistry, Chemical Engineering and Materials Science, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Institute of Molecular and Nano Science, Shandong Normal University, Jinan 250014, P. R. China.

Published: December 2021

AI Article Synopsis

Article Abstract

We report here a catalytically active nano covalent organic framework [COF(Fe)] with high drug loading capacity for reversing tumor multidrug resistance (MDR). The Fe catalytic sites in COF(Fe) could convert intracellular overexpressed HO into highly reactive ˙OH to induce oxidation stress and down-regulate MDR protein. Therefore, COF(Fe) could enhance the intracellular drug accumulation to overcome MDR, which was demonstrated both and .

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Source
http://dx.doi.org/10.1039/d1cc04414aDOI Listing

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