AI Article Synopsis
- TNF-α inhibitors, used for managing autoimmune diseases like psoriasis and rheumatoid arthritis, can lead to mycobacterial and opportunistic infections.
- Most mycobacterial infections in these patients are related to atypical mycobacteria, frequently presenting as pulmonary or disseminated infections.
- The case discussed highlights a rare instance of atypical mycobacterial tenosynovitis in a patient using adalimumab for psoriasis, emphasizing the need for awareness among prescribers.
Article Abstract
Tumor necrosis factor-alpha (TNF-α) inhibitors indicated in the management of psoriasis, rheumatoid arthritis, ulcerative colitis, Crohn's disease, and other autoimmune diseases have been associated with the development of mycobacterial and other opportunistic infections. The majority of mycobacterial infections diagnosed in patients taking TNF-α inhibitors are secondary to . Atypical mycobacteria have also been identified in this patient population, most commonly manifested by pulmonary or disseminated infections. Extra-pulmonary manifestations such as bone and joint infections are rare. We describe a case of atypical mycobacterial tenosynovitis in the setting of adalimumab use in a patient with psoriasis. This is a rarely reported complication that one should be aware of when prescribing these medications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8604424 | PMC |
| http://dx.doi.org/10.7759/cureus.18952 | DOI Listing |
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