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Line-field confocal optical coherence tomography: Characteristic hints for the diagnosis of scarring alopecia due to lupus erythematodes: A preliminary study.
Skin Res Technol
August 2024
Department of Dermatology and Allergy, LMU University Hospital, LMU Munich, Munich, Germany.
Article Synopsis
- Lupus erythematosus (LE) is an autoimmune disease that can lead to scarring alopecia, particularly in its discoid and panniculitis forms, complicating diagnosis for clinicians due to diverse symptoms.
- This study aimed to assess line-field confocal optical coherence tomography (LC-OCT) as a diagnostic tool for identifying features of cicatricial alopecia associated with LE.
- Results showed that LC-OCT successfully identified specific morphologic characteristics of cicatricial alopecia, including lymphocytic interface dermatitis and hyperreflective collagen fibers, which could aid in differentiating LE-related alopecia from other scarring types.
[What is proven in the treatment of systemic lupus erythematosus?].
Z Rheumatol
August 2024
Klinik für Rheumatologie und Immunologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland.
Systemic lupus erythematosus (SLE) is an autoimmune disease with variable clinical presentation and organ involvement. Early diagnosis and rapid achievement of low disease activity or remission reduces organ damage and improves prognosis. Therapeutic principles can be divided into so-called basic measures and immunosuppressive treatment.
View Article and Find Full Text PDF[EULAR recommendations 2023 on the treatment of systemic lupus erythematosus -Implications for treatment in Germany].
Z Rheumatol
August 2024
Bereich Rheumatologie, Medizinische Klinik und Poliklinik III und Universitätscentrum für Autoimmun- und Rheumatische Erkrankungen (UCARE), Universitätsklinikum und Medizinische Fakultät TU Dresden, Fetscherstr. 74, 01307, Dresden, Deutschland.
The 2023 update of the EULAR recommendations for the management of systemic lupus erythematosus (SLE) faced several tasks: the newly approved medications anifrolumab and voclosporin as well as the additional approval of belimumab for lupus nephritis had to be conceptionally fitted into the management of SLE. Novel data on hydroxychloroquine and glucocorticoids, additional results for the treat-to-target goals remission and low disease activity and experience with respect to vaccinations and infections had to be considered. Additionally, EULAR specified a slightly modified structure.
View Article and Find Full Text PDF[Ultraviolet radiation in the pathogenesis of lupus erythematosus].
Dermatologie (Heidelb)
July 2024
Klinik und Poliklinik für Dermatologie, Universität Düsseldorf, Düsseldorf, Deutschland.
Article Synopsis
- Photosensitivity in lupus erythematosus leads to heightened inflammation from sunlight, affecting both skin (cutaneous lupus) and systemic health (systemic lupus).
- UV radiation can trigger skin damage in cutaneous lupus, causing both temporary and permanent changes, while in systemic lupus, it may worsen the overall condition.
- Understanding the mechanisms behind UV-induced immune responses is essential for creating strategies to prevent or mitigate the harmful effects of photosensitivity, as the only current prevention method is to avoid UV exposure.
[CAR T-cell therapy in rheumatology-What we know so far?].
Z Rheumatol
August 2024
Medizinische Klinik 3 - Rheumatologie und Immunologie, Friedrich-Alexander-Universität Erlangen-Nürnberg und Universitätsklinikum Erlangen, 91054, Erlangen, Deutschland.
Autoreactive B‑cells play a key role in the pathogenesis of autoimmune diseases, such systemic lupus erythematosus (SLE). An efficient depletion of B‑cells therefore plays a special role in autoimmune diseases, especially in cases with a severe course of the disease. Treatment with chimeric antigen receptor (CAR) T‑cells, which was originally developed for the treatment of B‑cell lymphomas and leukemias, provides the possibility to deplete B‑cells even in deep tissues.
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