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Restoring hematopoietic stem and progenitor cell function in mice by delivery of RNA lipid nanoparticles.
Mol Ther Nucleic Acids
March 2025
Comprehensive Bone Marrow Failure Center, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Fanconi anemia (FA) is a congenital multisystem disorder characterized by early-onset bone marrow failure (BMF) and cancer susceptibility. While gene addition and repair therapies are being considered as treatment options, depleted hematopoietic stem cell (HSC) pools, poor HSC mobilization, compromised survival during transduction, and increased sensitivity to conventional conditioning strategies limit eligibility for FA patients to receive gene therapies. As an alternative approach, we explored protein replacement by mRNA delivery via lipid nanoparticles (LNPs).
View Article and Find Full Text PDFHow can consumer science help the foodservice industry replace meat? A critical review.
Appetite
January 2025
Örebro University, School of Hospitality and Meal Science.
In the pursuit of more sustainable diets, researchers have been studying ways to promote a transition from animal- to plant-based meals in foodservice contexts by influencing participants' conscious choices through names, labels, claims, and information. This critical review found that these interventions usually mobilize only those already engaged in reducing the consumption of animal products and often only during the intervention period, failing to influence those who eat most meat or to create long-lasting effects. Analyzing the choice for vegetarian meals against meals with meat in recently published studies conducted in foodservice contexts, we argue that the transition to more sustainable diets should rely less on consumers' willpower and more on public policies and institutional measures that change the availability, price, and visibility of plant-based meals.
View Article and Find Full Text PDFFish Meal Replacement by Chicken By-Product Meal in Diet: Impacts on Growth and Feed Availability of Juvenile Rockfish (), and Economical Analysis.
Animals (Basel)
January 2025
Division of Convergence on Marine Science, Korea Maritime and Ocean University, Busan 49112, Republic of Korea.
A 56-day feeding experiment was carried out to evaluate the effects of substituting fish meal (FM) with chicken by-product meal (CBM) in diets on the growth and feed utilization of rockfish (). Six experimental diets were formulated to be isonitrogenous and isolipidic. The control (Con) diet included 55% FM.
View Article and Find Full Text PDFYOLOv7-CWFD for real time detection of bolt defects on transmission lines.
Sci Rep
January 2025
School of Information, Yunnan University, Kunming, 650504, China.
Detecting bolt defects on transmission lines is crucial for ensuring the safe operation of the electrical power system. However, existing methods for detecting bolt defects on transmission lines require higher detection accuracy and smaller model sizes. To address these challenges, this paper proposes a real-time bolt defect detection model based on YOLOv7, named YOLOv7-CWFD.
View Article and Find Full Text PDFEpilepsy Arabic renaming to cerebroelectric disorder could minimize the stigma.
Epilepsy Res
December 2024
Department of Neurology, Faculty of Medicine, Cairo University, Cairo, Egypt. Electronic address:
Background: Naming is an important part of human communication. The precision of medical terms greatly influences the patients and their caregivers. "Alsara'الصرع " is the Arabic term defining epilepsy.
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