AI Article Synopsis
- - Diabetes is one of the leading causes of death globally among noncommunicable diseases, and Roselle (Hibiscus sabdariffa) has shown promise in helping manage blood sugar levels.
- - The exact mechanism by which Roselle acts as an anti-diabetic treatment remains unclear, but this study explores its protective effects on vascular endothelial cells.
- - Using network pharmacology combined with experimental methods, the study identified active ingredients in Roselle and analyzed their potential molecular mechanisms, laying the groundwork for its development as a diabetes treatment.
Article Abstract
Diabetes mellitus is one of the top four leading causes of death among noncommunicable diseases worldwide, according to the World Hibiscus sabdariffa 2019. Roselle (Hibiscus sabdariffa L.), a traditional herbal medicine, has shown significant clinical anti-hyperglycemic efficacy. However, the mechanism of the treatment is not yet clear. We found that Roselle has a certain protective effect on vascular endothelial cells through this study. This study was based on network pharmacology and experimental validation. The present study made a comprehensive analysis by combining active ingredient screening, target prediction and signaling pathway analysis to elucidate the active ingredients and possible molecular mechanism of roselle for the first time, which provided theoretical and experimental basis for the development and application of roselle as an antidiabetic drug.
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| http://dx.doi.org/10.1016/j.compbiomed.2021.104636 | DOI Listing |
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