In this work, we obtain extremely low confinement-loss (CL) anti-resonant fibers (ARFs) via swarm intelligence, specifically the particle swarm optimization (PSO) algorithm. We construct a complex search space of ARFs with two layers of cladding and nested tubes. There are three and four structures of cladding tubes in the first and second layer, respectively. The ARFs are optimized by using the PSO algorithm in terms of both the structures and the parameters. The optimal structure is obtained from a total of 415900 ARFs structures, with the lowest CL being 2.839×10 dB/m at a wavelength of 1.55 µm. We observe that the number of ARF structures with CL less than 1×10 dB/m in our search space is 370. These structures mainly comprise four designs of ARFs. The results show that the optimal ARF structures realized by the PSO algorithm are different from the ARFs reported in the previous literature. This means that the swarm intelligence accelerates the design and invention of ARFs and also provides new insights regarding the ARF structures. This work provides a fast and effective approach to design ARFs with special requirements. In addition to providing high-performance ARF structures, this work transforms the ARF designs from experience-driven to data-driven.
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http://dx.doi.org/10.1364/OE.440949 | DOI Listing |
PLoS Comput Biol
December 2024
Insigneo Institute for in Silico Medicine, University of Sheffield, Sheffield, United Kingdom.
Neuroblastoma is the most common extra-cranial solid tumour in children. Over half of all high-risk cases are expected to succumb to the disease even after chemotherapy, surgery, and immunotherapy. Although the importance of MYCN amplification in this disease is indisputable, the mechanistic details remain enigmatic.
View Article and Find Full Text PDFEMBO Rep
December 2024
Pharmacology Division, CSIR-Central Drug Research Institute, Lucknow, India.
Salmonella enterica serotype Typhimurium (Salmonella) resides and multiplies intracellularly in cholesterol-rich compartments called Salmonella-containing vacuoles (SCVs) with actin-rich tubular extensions known as Salmonella-induced filaments (SIFs). SCV maturation depends on host-derived cholesterol, but the transport mechanism of low-density lipoprotein (LDL)-derived cholesterol to SCVs remains unclear. Here we find that peroxisomes are recruited to SCVs and function as pro-bacterial organelle.
View Article and Find Full Text PDFJ Am Chem Soc
December 2024
Department of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, United States.
Small GTPases (smG) are a 150-member family of proteins, comprising five subfamilies: Ras, Rho, Arf, Rab, and Ran-GTPases. These proteins function as molecular switches, toggling between two distinct nucleotide-bound states. Using traditional multidimensional heteronuclear NMR, even for single smGs, numerous experiments, high protein concentrations, expensive isotope labeling, and long analysis times are necessary.
View Article and Find Full Text PDFPlant Physiol Biochem
December 2024
College of Landscape Architecture and Forestry, Qingdao Agricultural University, Qingdao, 266109, China; State Key Laboratory of Subtropical Silviculture, Zhejiang A&F University, Hangzhou, 311300, China. Electronic address:
Auxin response factors (ARFs) are key transcriptional factors mediating the transcriptional of auxin-related genes that play crucial roles in a range of plant metabolic activities. The characteristics of 47 PeARFs, identified in moso bamboo and divided into three classes, were evaluated. Structural feature analysis showed that intron numbers ranged from 3 to 14, while Motif 1, 2, 7 and 10 were highly conserved, altogether forming DNA-binding and ARF domains.
View Article and Find Full Text PDFExp Neurol
December 2024
Department of Neurological Surgery, Weill Institute for Neurosciences, Brain and Spinal Injury Center, University of California San Francisco, San Francisco, CA, USA; Department of Physical Therapy, Faculty of Rehabilitation Medicine, Institute for Neuroscience and Mental Health, University of Alberta, Edmonton, Alberta, Canada; School of Public Health Sciences, Faculty of Health, University of Waterloo, Waterloo, Ontario, Canada. Electronic address:
Data interoperability is crucial for effectively combining data for scientific inquiry. To facilitate interoperability, data standards such as a common definition of variables are often developed. The Open Data Commons for Spinal Cord Injury (odc-sci.
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