AI Article Synopsis
- A systematic review was conducted to compare the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years) versus older patients (>40 years).
- The study utilized four databases and identified 12 eligible studies after analyzing 118 full texts, finding that young patients had a higher relapse rate.
- Although the 5-year overall survival rates were similar for both age groups, the young group experienced worse disease-free survival and more relapses.
Article Abstract
To perform a systematic review focusing on the prognosis of oral cavity squamous cell carcinoma (OSCC) in young patients (≤40 years old) compared to older (>40 years old). Four databases were used in our search strategy. First, all titles were systematically organized using the Covidence platform online. In the second phase, 118 full texts of potentially eligible studies were analyzed by reviewers independently and in pairs. Twelve studies were considered eligible for data extraction. The relapse was higher in the young than in controls (pooled relative risk (RR) = 1.31; 95% CI [1.10-1.56]). The 5-year disease-free survival (DFS) was worse in young group (pooled hazard ratio (HR) = 0.73; 95% CI [0.63-0.85]) but the 5-year overall survival (OS) estimate was similar between the groups (pooled HR = 0.84; 95% CI [0.70-1.00]). While the 5-year OS was similar between groups, the number of relapses and 5-year DFS were worse in patients with OSCC ≤40 years old.
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| http://dx.doi.org/10.1002/hed.26940 | DOI Listing |
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