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Evidence of compensatory neural hyperactivity in a subgroup of breast cancer survivors treated with chemotherapy and its association with brain aging.
Front Aging Neurosci
December 2024
Division of Adult Health, School of Nursing, University of Texas at Austin, Austin, TX, United States.
Introduction: Chemotherapy-related cognitive impairment (CRCI) remains poorly understood in terms of the mechanisms of cognitive decline. Neural hyperactivity has been reported on average in cancer survivors, but it is unclear which patients demonstrate this neurophenotype, limiting precision medicine in this population.
Methods: We evaluated a retrospective sample of 80 breast cancer survivors and 80 non-cancer controls, aged 35-73, for which we had previously identified and validated three data-driven, biological subgroups (biotypes) of CRCI.
Association between thyroid hormone sensitivity and carotid plaque risk: a health examination cohort-based study.
Front Endocrinol (Lausanne)
December 2024
Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Introduction: The involvement of thyroid hormone in cardiovascular disease remains debated. The aim of our research was to ascertain whether thyroid hormone sensitivity indices are related to carotid plaque (CAP) risk in the general population.
Methods: We recruited 5,360 participants for health examinations to explore the correlation between thyroid hormone sensitivity indices and CAP risk.
Elevated cell-free hemoglobin: A novel early biomarker following traumatic injury.
J Trauma Acute Care Surg
December 2024
From the Department of Surgery (J.T.R.), and Blood, Heart, Lung, and Immunology Research Center (J.T.R., K.E.R.), University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; Department of Surgery (A.J.R., A.B., A.R.B., R.A.C.), University of California Davis, Sacramento, California; Department of Anesthesia and Critical Care (A.M., N.N.), Pontchaillou University Hospital of Rennes, Rennes, France; Department of Anesthesiology and Perioperative Medicine (J.D.R.), University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; and Division of Pulmonary Critical Care Medicine, Department of Medicine (K.E.R.), University Hospitals of Cleveland, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Background: Cell-free hemoglobin (CFH) and free heme are potent mediators of endotheliopathy and organ injury in sepsis, but their roles in other hemolytic pathologies are not well-defined. A prime example is trauma where early hemolysis may initiate damage and predict outcome. Here, we investigated the presence of plasma CFH, heme, and their major scavengers after traumatic injury.
View Article and Find Full Text PDFClinical outcomes of Xen 45 gel stent implantation(Ab externo, open conjunctival approach) versus Trabeculectomy: A real world study.
Korean J Ophthalmol
December 2024
Department of Ophthalmology, Institute of Vision Research, Severance Eye Hospital, Yonsei University College of Medicine, South Korea.
Purpose: To compare the clinical outcomes of Xen 45 gel stent implantation surgery (Ab externo, open conjunctiva) with those of trabeculectomy.
Method: We retrospectively reviewed electronic medical record of 57patients (62eyes) treated with Xen implantation surgery (ab externo, open conjunctiva approach) between April 1st, 2021 and July 31st, 2023 by the same surgeon. Preoperative clinical data including intraocular pressure, the number of glaucoma medications, visual acuity were collected from 1 day to 12 months postoperatively.
Profileplasty: Comprehensive Facial Profile Management Algorithm Based on 426 Patients.
J Craniofac Surg
December 2024
Private Practice, Guilford, CT.
Objective: Profileplasty traditionally involves improving a nasal hump or an underprojected chin. However, this procedure can correct other facial defects like saddle nose or prognathism. To establish the best overall profile, the nose, the midface, and the chin should be considered altogether.
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