AI Article Synopsis
- Hydrogels serve as effective 3D scaffolds for various applications including cell culture, drug delivery, and regenerative medicine.
- A new chemical cross-linking method using diethyl squarate was used to create gelatin-based hydrogels at concentrations of 5% and 10% w/v.
- The 5% gelatin hydrogel demonstrated excellent swelling properties and was found suitable for culturing chondrocyte cells, while also allowing for the study of how different sized molecules diffuse within it.
Article Abstract
Hydrogels are useful platforms as three-dimensional (3D) scaffolds for cell culture, drug-release systems, and regenerative medicine applications. Here, we propose a novel chemical cross-linking approach by the use of 3,4-diethoxy-3-cyclobutene-1,2-dione or diethyl squarate for the preparation of 5 and 10% w/v gelatin-based hydrogels. Hydrogels showed good swelling properties, and the 5% gelatin-based hydrogel proved suitable as a 3D cell culture scaffold for the chondrocyte cell line C28/I2. In addition, diffusion properties of different sized molecules inside the hydrogel were determined.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8655982 | PMC |
| http://dx.doi.org/10.1021/acs.langmuir.1c02080 | DOI Listing |
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