shows no ameliorative potential on ovariectomy-induced hormonal and estrous cycle dysregulation in normal cyclic rats: An experimental study.

Int J Reprod Biomed

Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Nigeria.

Published: October 2021

AI Article Synopsis

  • The study explores the effects of a plant extract (MEPO) on reproductive health in rats after ovariectomy, a procedure that mimics menopause.
  • The research involved four groups of rats, with one group not receiving any treatment, while others were given different doses of MEPO for 14 days.
  • Results indicated that MEPO did not improve hormone levels or restore normal estrous cycles in the ovariectomized rats, suggesting its ineffectiveness for this particular issue.

Article Abstract

Background: (PO) is a widely known plant utilized for its medicinal attributes in the treatment of different illnesses.

Objective: To investigate the effect of methanolic extract of PO (MEPO) on ovariectomy-induced reproductive toxicity in normal cyclic rats.

Materials And Methods: Twenty 10-wk-old normal cyclic rats weighing 110-200 g were randomly divided into four groups (n = 5/group). Group A served as the control and received distilled water only. Group B was ovariectomized without treatment, while groups C and D were ovariectomized but treated with 400 and 800 mg/kg of MEPO, respectively, for 14 days. At the end of the experiment, body weight, serum hormonal levels, and estrous cycles were monitored across the groups.

Results: Groups B, C, and D showed estrous cycle dysregulation and specific phase arrest when compared with the control. While a significant decrease in estradiol (p 0.001) and testosterone levels (p 0.001) were observed in groups B, C, and D, only groups C and D showed a significant increase in progesterone level when compared with the control (p 0.001, p = 0.01, respectively).

Conclusion: The administration of 400 and 800 mg/kg MEPO is ineffective in ameliorating estrous cycle disruption and hormonal changes seen in ovariectomized normal cyclic adult Wistar rats.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8595911PMC
http://dx.doi.org/10.18502/ijrm.v19i10.9822DOI Listing

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