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| http://dx.doi.org/10.1253/circrep.CR-21-0124 | DOI Listing |
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Therapeutic potential of ketone bodies on exercise intolerance in heart failure: looking beyond the heart.
Cardiovasc Res
January 2025
Cardiovascular Research Centre, University of Alberta, Edmonton, Alberta, Canada.
Recent evidence suggests that ketone bodies have therapeutic potential in many cardiovascular diseases including heart failure (HF). Accordingly, this has led to multiple clinical trials that use ketone esters to treat HF patients, which we term ketone therapy. Ketone esters, specifically ketone monoesters, are synthetic compounds which, when consumed, are de-esterified into two β-hydroxybutyrate (βOHB) molecules and increase the circulating βOHB concentration.
View Article and Find Full Text PDFNovel c.221+1dup pathogenic variant in AGK gene linked to Sengers syndrome.
Neuromuscul Disord
December 2024
University of Florida College of Medicine - Jacksonville, Jacksonville, FL, USA.
Sengers Syndrome (SS) is a rare autosomal recessive mitochondrial disorder caused by mutations in the acylglycerol kinase (AGK) gene on chromosome 7, also known as cardiomyopathic mitochondrial DNA depletion syndrome (MTDPS10). This disorder disrupts mitochondrial DNA function and energy metabolism, presenting with symptoms such as congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Previous research has shown SS affects oxidative phosphorylation and mitochondrial respiration, implicating the TIM22 complex and carrier import.
View Article and Find Full Text PDFAcute exacerbation of COPD: Physiotherapy practice and factors that influence management.
S Afr J Physiother
December 2024
Department of Physiotherapy, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is a leading cause of morbidity and mortality in South Africa. Physiotherapy practice and factors that influence management of patients with AECOPD are unknown.
Objectives: To explore physiotherapy practice in the management of patients with AECOPD in South African private healthcare settings and to identify and describe factors that influence physiotherapy patient management.
Low back pain treatment adherence barriers in Eswatini private physiotherapy practices: A pilot study.
S Afr J Physiother
December 2024
Department of Physiotherapy, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Background: Adherence to management regimes is pivotal to successfully managing patients with low back pain (LBP). Barriers decrease adherence, resulting in disability.
Objectives: Our pilot study aimed to determine barriers associated with physiotherapy treatment attendance and home exercise programme adherence among patients with LBP and treating physiotherapists in Eswatini.
Efficacy of aerobic exercise for HIV-associated neurocognitive disorders receiving ART: An RCT.
S Afr J Physiother
December 2024
Department of Physiotherapy, Faculty of Health Sciences, University of Pretoria, Pretoria North, South Africa.
Background: HIV-associated neurocognitive disorder (HAND) affects an individual's capacity for independence and engagement in everyday activities, posing challenges in environments with limited resources and low social support.
Objectives: To ascertain the efficacy of exercise (AE) for activity and participation (AP) level in people with HAND.
Method: This is a randomised controlled trial that is parallel-group in nature, with intention-to-treat analysis and disguised allocation.
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