AI Article Synopsis
- The study of Chinese herbal medicines for chronic kidney disease has progressed over 40 years, revealing clinical efficacy and mechanisms of action.
- Five key herbs have shown strong evidence of effectiveness: including components such as tanshinone II A and triptolide.
- These herbs exhibit pharmaceutical benefits by combating fibrosis, inflammation, and oxidative stress while promoting renal repair and regeneration.
Article Abstract
The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: and , and its components (tanshinone II A, salvianolic acid A and B); and its monomer ; and its components (triptolide, tripterygium glycosides); Kudzu root and its monomer . These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8599578 | PMC |
| http://dx.doi.org/10.3389/fphar.2021.774414 | DOI Listing |
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