Objective: To compare the sedative and cardiopulmonary effects of intranasal (IN) and intramuscular (IM) administration of dexmedetomidine and midazolam combination in New Zealand White rabbits.
Study Design: A randomized, crossover experimental study.
Animals: A total of eight healthy New Zealand White rabbits, aged 6-12 months, weighing 3.1 ± 0.3 kg (mean ± standard deviation).
Methods: The animals were randomly assigned to administration of dexmedetomidine (0.1 mg kg) with midazolam (2 mg kg) by either IN or IM route separated by 2 weeks. The electrocardiogram, pulse rate (PR), peripheral haemoglobin oxygen saturation (SpO), mean noninvasive arterial pressure (MAP), respiratory frequency (f) and rectal temperature were measured before drug administration (baseline), T (onset of sedation) and at 5 minute intervals until recovery. The onset of sedation, duration of sedation and sedation score (SS) were also recorded.
Results: The PR was significantly lower in treatment IM than in treatment IN over time (p = 0.027). MAP < 60 mmHg developed in two and four rabbits in treatments IN and IM, respectively. SpO progressively decreased over time in both treatments. f was lower than baseline at several time points in both treatments. Onset of sedation was shorter in treatment IN (90 ± 21 seconds) than in treatment IM (300 ± 68 seconds) (p = 0.036). Duration of sedation was longer in treatment IM (55.2 ± 8.7 minutes) than in treatment IN (39.6 ± 2.1 minutes) (p = 0.047). No significant difference in SS was observed between treatments (p > 0.05).
Conclusions And Clinical Relevance: Combination of dexmedetomidine (0.1 mg kg) and midazolam (2 mg kg) decreased f, PR and SpO regardless of the administration route in New Zealand White rabbits. A more rapid action and shorter duration of sedation were observed after treatment IN than after treatment IM administration.
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| http://dx.doi.org/10.1016/j.vaa.2021.10.003 | DOI Listing |
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