AI Article Synopsis
- Five new cyclohexene derivatives and 16 known secondary metabolites were isolated from the stem and root barks, characterized using NMR and mass spectrometry, with one structure confirmed by X-ray crystallography.
- The metabolites were tested for antibacterial activity against various Gram-positive and Gram-negative bacteria as well as for cytotoxicity against the MCF-7 human breast cancer cell line.
- Notably, a combination of uvaretin and isouvaretin showed significant antibacterial effects, while (8'α,9'β-dihydroxy)-3-farnesylindole demonstrated strong inhibition against a specific bacteria, comparable to ampicillin, but all compounds had no significant cytotoxicity against cancer cells.
Article Abstract
Five new cyclohexene derivatives, dipandensin A and B ( and ) and pandensenols A-C (-), and 16 known secondary metabolites (-) were isolated from the methanol-soluble extracts of the stem and root barks of . The structures were characterized by NMR spectroscopic and mass spectrometric analyses, and that of 6-methoxyzeylenol () was further confirmed by single-crystal X-ray crystallography, which also established its absolute configuration. The isolated metabolites were evaluated for antibacterial activity against the Gram-positive bacteria and and the Gram-negative bacteria , , , , and , as well as for cytotoxicity against the MCF-7 human breast cancer cell line. A mixture of uvaretin () and isouvaretin () exhibited significant antibacterial activity against (EC 8.7 μM) and (IC 7.9 μM). (8'α,9'β-Dihydroxy)-3-farnesylindole () showed strong inhibitory activity (EC 9.8 μM) against , comparable to the clinical reference ampicillin (EC 17.9 μM). None of the compounds showed relevant cytotoxicity against the MCF-7 human breast cancer cell line.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8713284 | PMC |
| http://dx.doi.org/10.1021/acs.jnatprod.1c00811 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
From the depths of the Java Trench: genomic analysis of Priestia flexa JT4 reveals bioprospecting and lycopene production potential.
BMC Genomics
December 2024
Institut Teknologi Bandung, School of Life Sciences and Technology, Bandung, West Java, Indonesia.
Background: The marine environment boasts distinctive physical, chemical, and biological characteristics. While numerous studies have delved into the microbial ecology and biological potential of the marine environment, exploration of genetically encoded, deep-sea sourced secondary metabolites remains scarce. This study endeavors to investigate marine bioproducts derived from deep-sea water samples at a depth of 1,000 m in the Java Trench, Indonesia, utilizing both culture-dependent and whole-genome sequencing methods.
View Article and Find Full Text PDFLive Akkermansia muciniphila boosts dendritic cell retinoic acid synthesis to modulate IL-22 activity and mitigate colitis in mice.
Microbiome
December 2024
Department of Gastroenterology, Guangdong Provincial Key Laboratory of Gastroenterology, Institute of Gastroenterology of Guangdong Province, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Background: The interplay between gut microbiota and immune responses is crucial in ulcerative colitis (UC). Though Akkermansia muciniphila (Akk) shows therapeutic potential, the mechanisms remain unclear. This study sought to investigate differences in therapeutic efficacy among different forms or strains of Akk and elucidate the underlying mechanisms.
View Article and Find Full Text PDFFoeniculum vulgare Miller bracts, revalorization of a local food waste.
Sci Rep
December 2024
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, Fisciano, 84084, Salerno, Italy.
Article Synopsis
- The research investigates the potential of using fennel by-products from Southern Italy by analyzing their chemical properties and health benefits.
- The study identifies useful compounds in the extracts, like flavonoids and essential amino acids, and highlights trans-anethole and limonene as key components in essential oils.
- Results show that while the hydroalcoholic extracts have moderate antioxidant activity, the essential oils exhibit antimicrobial properties against several common bacteria, suggesting that fennel waste can be a valuable resource.
Omics-driven onboarding of the carotenoid producing red yeast Xanthophyllomyces dendrorhous CBS 6938.
Appl Microbiol Biotechnol
December 2024
Life Sciences and Bioengineering Center, Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, MA, USA.
Transcriptomics is a powerful approach for functional genomics and systems biology, yet it can also be used for genetic part discovery. Here, we derive constitutive and light-regulated promoters directly from transcriptomics data of the basidiomycete red yeast Xanthophyllomyces dendrorhous CBS 6938 (anamorph Phaffia rhodozyma) and use these promoters with other genetic elements to create a modular synthetic biology parts collection for this organism. X.
View Article and Find Full Text PDF[Effects of exogenous abscisic acid on grain filling characteristics, starch accumulation, and endogenous hormones in maize under early post-anthesis high temperature stress].
Ying Yong Sheng Tai Xue Bao
October 2024
College of Plant Protection, Shandong Agricultural University, Tai'an 271018, Shandong, China.
We investigated the effects of exogenous abscisic acid (ABA) on grain filling, starch accumulation, and endogenous hormones in maize (both the heat-tolerant maize variety Zhengdan 958 (ZD958) and the heat-sensitive variety Xianyu 335 (XY335)) under early post-anthesis high temperature stress by simulating high temperature stress for a period of 6 to 12 days post-anthesis in 2022 and 2023. There were three treatments: spraying water at ambient temperature as the control, spraying water at high temperature, and spraying ABA at high temperature. The results showed that early post-anthesis high temperature stress resulted in a significant reduction in grain weight and yield in maize, with XY335 showing a greater reduction than ZD958.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!