AI Article Synopsis
- Melanoma is highly prevalent in gray horses, with rates exceeding 50%, and genetic predisposition has been linked to a specific duplication in the STX17 gene.
- A study conducted a genome-wide association analysis on 141 Lipizzan horses, identifying the DPF3 gene on chromosome 24 as a potential factor in melanoma development.
- Further research involving 1210 horses from multiple breeds suggests that a specific genotype of the DPF3 gene may help suppress melanoma, highlighting its importance for gray horses at risk of developing this condition.
Article Abstract
Melanoma prevalence in gray horses reaches up to 50% and more. Several studies have documented a genetic melanoma predisposition which is referred to the 4.6 kb duplication in intron 6 of STX17 and its surrounding haplotype. However, the genetic background and mechanisms responsible for differences in etiopathogenesis of equine dermal melanomatosis still remain unknown. In the current study, we performed a genome wide association analysis in 141 Lipizzan horses and subsequently identified one candidate gene on chromosome 24 putatively involved in melanoma pathogenesis in gray horses. The associated SNP was located in the intronic region of DPF3, a gene which is involved in humans in cell growth, proliferation, apoptosis and motility of cancer cells. The replication study in 1210 horses from seven breeds demonstrated, that the G/G genotype of the DPF3 associated SNP exhibits putative melanoma suppression effects. As a conclusion DPF3 represents a candidate gene, which might play an essential role for gray horses coping with high genetic melanoma related tumor load.
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| http://dx.doi.org/10.1016/j.jevs.2021.103797 | DOI Listing |
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