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Genetic Assessment of Living Kidney Transplant Donors: A Survey of Canadian Practices.
Can J Kidney Health Dis
January 2025
Multiorgan Transplant Program, Division of Nephrology, Department of Medicine, McGill University Health Centre, Montreal, QC, Canada.
Background: Kidney failure is a prevalent condition with tendency for familial clustering in up to 27% of the affected individuals. Living kidney donor (LKD) transplantation is the optimal treatment option; however, in Canada, more than 45% of LKDs are biologically related to their recipients which subjects recipients to worse graft survival and donors to higher future risk of kidney failure. Although not fully understood, this observation could be partially explained by genetic predisposition to kidney diseases.
View Article and Find Full Text PDFEmerging role of genetics in kidney transplantation.
Kidney Int
December 2024
Institute of Systems Genetics, New York University Langone Health, Grossman School of Medicine, New York, New York, USA. Electronic address:
The advent of more affordable genomic analytical pipelines has facilitated the expansion of genetic studies in kidney transplantation. Advances in genetic sequencing have allowed for a greater understanding of the genetic basis of chronic kidney disease, which has helped to guide transplant management and address issues related to living donation in specific disease settings. Recent efforts have shown significant effects of genetic ancestry and donor APOL1 risk genotypes in determining worse allograft outcomes and increased donation risks.
View Article and Find Full Text PDFAttitudes Toward Use of an APOL1 Genetic Testing Chatbot in Living Kidney Donor Evaluation: A Focus Group Study.
Clin Transplant
December 2024
Department of Surgery I Center for Biomedical Ethics and Society, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Article Synopsis
- The study explores attitudes of living kidney donor candidates of African ancestry toward using the Gia chatbot for Apolipoprotein L1 (APOL1) genetic testing during the donor evaluation process.
- Focus groups with 54 participants revealed that most supported the use of the chatbot prior to clinic visits and expressed interest in APOL1 testing after utilizing the technology.
- However, concerns about testing costs and individual preferences for chatbot usage in healthcare settings emerged as potential barriers to widespread adoption.
[Genetics in nephrology - any news?].
Dtsch Med Wochenschr
November 2024
Klinik II für Innere Medizin - Nephrologie, Rheumatologie, Diabetologie und Allgemeine Innere Medizin, Uniklinik Köln, Köln, Deutschland.
While genetic kidney diseases were long regarded as a rare cause of kidney failure, it has been shown in recent years that they account for a relevant proportion of cases. In cohorts of kidney transplant recipients, a monogenic cause is found in up to 30% of cases. Identifying the genetic cause of kidney disease has become much easier thanks to technological advances in DNA sequencing.
View Article and Find Full Text PDFA pragmatic approach to selective genetic testing in kidney transplant candidates.
Front Transplant
January 2024
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Introduction: Advances in the field of genetic testing have spurred its use in transplantation. Potential benefits of genetic testing in transplant nephrology include diagnosis, treatment, risk stratification of recurrent disease, and risk stratification in potential donors. However, it is unclear how to best apply genetic testing in this population to maximize its yield.
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