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Pembrolizumab in microsatellite instability-high/mismatch repair deficient (MSI-H/dMMR) and non-MSI-H/non-dMMR advanced endometrial cancer: Phase 2 KEYNOTE-158 study results.
Gynecol Oncol
January 2025
University of Siena and Center for Immuno-Oncology, Department of Oncology, University Hospital, Siena, Italy. Electronic address:
Objective: We report updated results with longer follow-up in patients with MSI-H/dMMR endometrial cancer (EC) in cohort D (advanced EC of any MSI/dMMR status) and cohort K (any MSI-H/dMMR advanced solid tumor, except colorectal) of the phase 2 KEYNOTE-158 study (NCT02628067) and the first results from patients with non-MSI-H/non-dMMR advanced EC (cohort D).
Methods: Patients received pembrolizumab 200 mg Q3W for ≥35 cycles. The primary endpoint was objective response rate (ORR) per RECIST v1.
The ANZSNP scientific meeting 2024 was held in the scenic city of Queenstown, New Zealand on 31 August and September 1. Dr Fouzia Ziad, President of the ANZSNP and Dr Laveniya Satgunaseelan, Secretary /Treasurer of the ANZSNP were the convenors of the meeting. The meeting was co-badged with the Australasian Winter Conference on Brain Research (AWCBR) 2024.
View Article and Find Full Text PDFA novel binary hashing for agricultural scenery classification.
Sci Rep
November 2024
College of Computer Sciences, Beijing Technology and Business University, Beijing, 102488, China.
In this research, we present PerceptHashing, a technique designed to categorize million-scale agricultural scenic images by incorporating human gaze shifting paths (GSPs) into a hashing framework. For each agricultural image, we identify visually and semantically significant object patches, such as fields, crops, and water bodies. These patches are linked to form a graphlet, establishing a network of spatially adjacent patches, and a GSP is then extracted using an active learning algorithm.
View Article and Find Full Text PDFUsing a Fitbit-based Walking Game to Improve Physical Activity Among U.S. Veterans.
Mil Med
January 2025
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA 52242, USA.
Introduction: Physical inactivity, hereafter inactivity, is a serious health problem among U.S. veterans, hereafter veterans.
View Article and Find Full Text PDFFrom random to precise: updated colon cancer screening and surveillance for inflammatory bowel disease.
Transl Gastroenterol Hepatol
April 2024
Department of Gastroenterology, Zucker School of Medicine at Hofstra/Northwell, New York, NY, USA.
Patients with inflammatory bowel disease (IBD) are at increased risk of developing colorectal cancer (CRC). The pathogenesis of CRC in IBD differs from sporadic cancer, with the burden of inflammation being an important contributing factor. Other risk factors for developing CRC in patients with Crohn's disease (CD) or ulcerative colitis (UC) includes a family history of CRC, personal history of dysplasia, history of strictures, or primary sclerosing cholangitis (PSC).
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