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Hydroxychloroquine-induced cardiomyopathy: role of cardiac magnetic resonance for the diagnosis and follow-up of a very rare entity-a case report.
Eur Heart J Case Rep
August 2024
Cardiology Department, La Paz University Hospital, Paseo de la Castellana, 261, 28046 Madrid, Spain.
Article Synopsis
- Hydroxychloroquine (HCQ) is used to treat diseases like systemic lupus erythematosus but can lead to adverse effects after long-term use, including heart issues.
- A case involved a 45-year-old woman who developed acute heart failure due to HCQ-induced cardiomyopathy, leading to structural heart changes despite stopping the medication.
- The importance of early diagnosis is highlighted, as stopping the drug can halt disease progression, but existing heart damage may remain.
Hydroxychloroquine-Induced Phospholipidosis - A Forgotten Complication of a Common Drug.
Indian J Nephrol
August 2023
Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India.
Article Synopsis
- Hydroxychloroquine (HCQ) is a medication often used to treat autoimmune diseases such as lupus, rheumatoid arthritis, and Sjogren's syndrome due to its ability to modulate the immune system.
- While generally safe and effective, HCQ can have serious side effects, including retinopathy and, in rare cases, cardiomyopathy.
- This report highlights two cases of phospholipidosis (a type of fat accumulation in cells) linked to HCQ, suggesting that it should be considered as a potential cause in patients experiencing ongoing proteinuria (protein in urine).
Hydroxychloroquine Induced Cardiotoxicity: A Case Series.
Rom J Intern Med
June 2024
3Department of Rheumatology, Mayo Clinic, Jacksonville, FL 32224, USA.
Hydroxychloroquine (HCQ) induced cardiotoxicity is a rare diagnosis and is often associated with chronic use of the medication. It has been shown that chronic HCQ use is associated with a drug-induced cardiomyopathy mainly driven by acquired lysosomal storage defects leading to hypertrophy and conduction abnormalities. As the only proven treatment is the discontinuation of the offending agent, prompt recognition is required to avoid further exposure to the drug and potential progression of disease.
View Article and Find Full Text PDFHydroxychloroquine-induced cardiomyopathy predominantly affecting the right ventricle.
Eur Heart J Cardiovasc Imaging
March 2024
Cardiology Department, Tondela-Viseu Hospital Center, Av. Rei Dom Duarte, Viseu 3504-509, Portugal.
Zinc's protective role against hydroxychloroquine-induced cardiac effects in adult male albino rats.
Saudi J Biol Sci
August 2023
Anatomy Department, Tanta College of Medicine, Egypt.
Background: Long exposure to Hydroxychloroquine (HCQ) has been complicated by some dangerous though infrequent cardiotoxicity.
Methods: A total of 40 normal adult male albino rats dispersed into 4 groups were used. Group 1 (Control group), Group II (HCQ treated group), Group III (zinc [Zn]-treated group), and Group IV (HCQ and Zn treated group).
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