AI Article Synopsis
- Herbal medicines have historically been significant in treating cardiovascular disorders, and this study focuses on the edible fruit of Grewia asiatica in relation to hypertension.
- The study utilized isolated atrial preparations from guinea pigs and rat aortic rings, finding that the crude ethanolic extract (Ga.Cr) reduced heart contractions and caused vasodilation in a dose-dependent manner.
- Results indicated that Ga.Cr may lower blood pressure by inhibiting calcium influx and utilizing nitric oxide pathways, suggesting its potential as a natural treatment for hypertension.
Article Abstract
In the management of cardiovascular disorders, medicines from herbal sources have played a vital role through centuries. The following study was commenced in order to lay possible pharmacological foundation associated with medicinal uses of edible fruit of Grewia asiatica in hypertension through in-vitro method. In this study isolated atrial preparation of Guinea pig was used where crude ethanolic extract of Grewia asiatica fruit (Ga.Cr) decreased the force and rate of spontaneous atrial contractions (0.03-10mg/kg). In isolated rat aortic ring preparations previously vasoconstricted by phenylephrine and High K, it also resulted in dose dependent vasodilation (0.01-10 mg/kg).In the presence of L-NAME, the relaxation curve of Ga.Cr was partially inhibited showing involvement of Nitric oxide (NO) mediated pathway. The speculative analysis contemplated that Ga.Cr has blood pressure reducing potentials through inhibition of Ca influx via Ca channels, its release from intracellular stores and through other means like NO mediated pathways.
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