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| http://dx.doi.org/10.1016/j.ajem.2021.11.016 | DOI Listing |
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One hallmark of cancer is the upregulation and dependency on glucose metabolism to fuel macromolecule biosynthesis and rapid proliferation. Despite significant pre-clinical effort to exploit this pathway, additional mechanistic insights are necessary to prioritize the diversity of metabolic adaptations upon acute loss of glucose metabolism. Here, we investigated a potent small molecule inhibitor to Class I glucose transporters, KL-11743, using glycolytic leukemia cell lines and patient-based model systems.
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Changchun Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Changchun, 130122, People's Republic of China.
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Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, China.
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Universal Scientific Education and Research Network (USERN), Tehran, Iran.
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