Amelioration of sodium fluoride induced oxidative stress by Bedd in mice.

Objectives: , endemic to Western Ghats of India is pharmacologically similar to and occasionally used as substitute in a well-known Ayurvedic uterine tonic . possess various biological properties, but there are no reports on The present study evaluated the pharmacological properties of and its efficacy in attenuating the sodium fluoride (NaF) induced oxidative stress in mice.

Methods: Antioxidant potential of methanolic extract of . (CTE) stem bark was evaluated using DPPH, superoxide radical scavenging and total antioxidant assays. The effect of CTE on mitigating NaF deteriorated redox status in the liver tissue of mice was evaluated. Functional groups in CTE were analyzed by FTIR analysis.

Results: CTE effectively scavenged the free radicals in condition. CTE could augment catalase (46.6%), superoxide dismutase (53.8%) activities and GSH level (48.1%) against NaF induced decline in the liver tissue of mice. The peroxidation of lipids was found to be decreased by 44.9% and tissue damage abated as inferred by histopathology. FTIR analysis revealed the presence of biologically active functional groups in CTE.

Conclusions: The study revealed the ameliorative effect of . against NaF induced deleterious effect in experimental animals by its potent antioxidant potential.