AI Article Synopsis
- - The study introduces a new method for isomerizing linear allylic imidic esters using a palladium catalyst and oxygen, which specifically produces β-amino aldehydes.
- - The process utilizes -butyl nitrite as the only redox cocatalyst to facilitate the reaction.
- - Butanol (BuOH) is identified as an essential solvent that enhances the yield and specificity of the desired Markovnikov aldehyde products.
Article Abstract
A tandem isomerization--Markovnikov oxidation of linear allylic imidic esters is developed using bis(benzonitrile)palladium chloride as the catalyst and O as the sole oxidant, regiospecifically giving β-amino aldehydes as the product. -Butyl nitrite works as a simple, and the only, redox cocatalyst. BuOH proves to be a crucial solvent for achieving excellent yield and specificity toward -Markovnikov aldehyde products.
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| http://dx.doi.org/10.1021/acs.orglett.1c03619 | DOI Listing |
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