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A tandem rhodium(III)-catalyzed system was established to access 3,4-dihydroisoquinolin-1(2)-one by coupling of -methoxy-3-methylbenzamide with 2-methylidenetrimethylene carbonate. This one-pot synthesis protocol processed smoothly under mild reaction conditions. Moreover, a total of 28 examples, broad substrate scope, and high functional-group compatibility were observed. Preliminary mechanism studies were also conducted and demonstrated that the rhodium(III) catalyst played a vital role in the C-H-allylation and N-alkylation cyclization process.
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| http://dx.doi.org/10.1021/acs.joc.1c02179 | DOI Listing |
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