AI Article Synopsis
- - Gagnep, a Vietnamese medicinal plant, has been studied for its chemical composition and anti-cancer properties, particularly focusing on its rhizome extract (CSE).
- - The study evaluated the cytotoxic effects of CSE on liver and breast cancer cells using different assays, finding significant cancer cell death while sparing normal cells, and showing a dose-dependent induction of apoptosis in specific cancer cell lines.
- - Key compounds identified in the extract included sesquiterpenes like germacrone, ar-turmerone, and curcumol, marking this research as the first to report on the anti-cancer activity of Gagnep's rhizomes.
Article Abstract
Gagnep is a Vietnamese medicinal plant which has been commonly used in traditional and folk medicines for the treatment of different diseases. The goals of the present study are to investigate chemical composition and anti-proliferative activity of rhizome extract (CSE). The cytotoxicity of CSE was evaluated using WST-1 and LDH assays. The apoptosis induction was determined using nuclei DAPI staining and FACS assays. The main compounds of extract were identified and quantitatively analyzed using the validated HPLC method. The extract showed cytotoxic effects in various liver and breast cancer cells but had minimal effects on normal cells. It induced apoptosis on both Hep3B and SKBR3 cells in a dose-dependent manner. In addition, three sesquiterpene compounds, such as germacrone (3.25 ± 0.32 mg/g), ar-turmerone (1.12 ± 0.24 mg/g), and curcumol (0.31 ± 0.12 mg/g) were found as the main components of CSE. This is the first report on the cytotoxic effect of rhizomes against cancer cells.
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| http://dx.doi.org/10.1080/14786419.2021.2005595 | DOI Listing |
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