Morphological factors affecting vortex core instability on 4D flow MRI of unruptured cerebral aneurysms.

Objective: The spatiotemporal instability of intra-aneurysmal vortex flow may be associated with unruptured cerebral aneurysm rupture. We identified morphological factors that affect intra-aneurysmal vortex core patterns classified based on the instability on four-dimensional (4D) flow magnetic resonance imaging (MRI) and determined cutoff values for the factors to discriminate unstable core patterns.

Methods: We classified vortex core patterns of 40 unruptured aneurysms on 4D flow MRI into stable, stable with a flapping tip, continuously deforming wave-or-coil-like, and non-visualized. We statistically compared nine morphological parameters among aneurysm groups with individual patterns.

Results: The vortex cores were stable ( = 16) (group A), stable with a flapping tip ( = 15) (group B), wave-or-coil-like ( = 7) (group C), and non-visualized ( = 2) (group D). Since there were no statistically significant differences between groups A and B, we compared the difference between the groups A and B and the other groups. Multivariate logistic regression analyses found that size ratio (SR) was an only independently significant parameter ( < 0.05). The receiver-operating characteristic analysis between groups A and B and group C and between groups A and B and groups C and D revealed that the area under the curve value for SR was the highest (0.829 [95% CI, 0.642-1.0]; 0.867 [95% CI, 0.715-1.0], respectively) among morphological factors; the cutoff value for SR was 1.72 (specificity 0.714, sensitivity 0.756; specificity 0.806, sensitivity 0.778, respectively).

Conclusion: SR was an independent morphological factor contributing to vortex core instability based on the vortex core patterns on 4D flow MRI. CFD: computational fluid dynamics; 3D: three-dimensional; 4D: four-dimensional; MRI: magnetic resonance imaging; MRA: magnetic resonance angiography; ICA: internal carotid artery; AR: aspect ratio; SR: size ratio; CI: confidence interval; AUC: area under the curve; ROC: receiver-operating characteristic.