A significant challenge in biomedicine is the development of Biomaterials with the potential to accelerate wound healing. The aim of this study was to investigate the effect of the gel prepared from sea cucumber on wound healing in rats. Full-thickness wounds were created in male rats divided into five experimental groups, negative control (NC), positive control (PC), and treatments. The NC and PC groups received respectively gel base and phenytoin cream 1%. Treatment groups were treated topically by gels of 1%, 3%, and 5% extract (HPE) in the gel base. The rats were sacrificed on days 7, 14, and 21. Pathological reports revealed the proliferation of keratinocytes in the borders of the wound in treatment groups and controls. Formation of granulation tissue was seen on day 7 in treatment groups, collagen fibers in granulation tissue were randomly organized, and the rate of fibroblast decreased. Results showed that there were statistically significant differences in wound contraction between all groups in comparison to the NC group ( < .05) on day 8. It was concluded that the 1% HPE gel has a good potential for promoting wound healing.
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