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Exploring the biological impact of bacteria-derived indole compounds on human cell health: Cytotoxicity and cell proliferation across six cell lines.
Toxicol Rep
June 2025
Department of Environmental Science, Baylor University, Waco, TX 76798, USA.
Over the past two decades, research has increasingly focused on the interactions between diet, gut microbiota, and host organisms. Recent evidence suggests that tryptophan, an essential amino acid, can be metabolized by gut microbiota into indoles, which have significant biological effects. However, most research is limited to indole and its liver metabolite, indoxyl sulfate.
View Article and Find Full Text PDFComparative study on the anti-alcoholic liver disease efficiency of the ethanol- and water-soluble polysaccharides from Baijiu vinasses.
Int J Biol Macromol
January 2025
Luzhou Laojiao Co, Ltd, Luzhou, Sichuan 646000, China; National Engineering Research Center of Solid-State Brewing, Luzhou, Sichuan 646000, China.
Ethanol- and water-soluble polysaccharides were extracted from Baijiu vinasses (EP and WP), respectively. EP was dominantly composed by arabinose, glucose and xylose with molar ratio of 8.81: 76.
View Article and Find Full Text PDFThe Metabolite Indole-3-Acetic Acid of Bacteroides Ovatus Improves Atherosclerosis by Restoring the Polarisation Balance of M1/M2 Macrophages and Inhibiting Inflammation.
Adv Sci (Weinh)
January 2025
Department of Cardiovascular Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330008, China.
Emerging research has highlighted the significant role of the gut microbiota in atherosclerosis (AS), with microbiota-targeted interventions offering promising therapeutic potential. A central component of this process is gut-derived metabolites, which play a crucial role in mediating the distal functioning of the microbiota. In this study, a comprehensive microbiome-metabolite analysis using fecal and serum samples from patients with atherosclerotic cardiovascular disease and volunteers with risk factors for coronary heart disease and culture histology is performed, and identified the core strain Bacteroides ovatus (B.
View Article and Find Full Text PDFWKB ameliorates DSS-induced colitis through inhibiting enteric glial cells activation and altering the intestinal microbiota.
J Transl Med
January 2025
Department of Gastroenterology, Air Force Medical Center, No. 30 Fucheng Road, Haidian District, Beijing, 100142, China.
Background: Inflammatory bowel disease (IBD) is a chronic condition influenced by diet, which affects gut microbiota and immune functions. The rising prevalence of IBD, linked to Western diets in developing countries, highlights the need for dietary interventions. This study aimed to assess the impact of white kidney beans (WKB) on gut inflammation and microbiota changes, focusing on their effects on enteric glial cells (EGCs) and immune activity in colitis.
View Article and Find Full Text PDFSingle-Template Molecularly Imprinted Chiral Sensor for Enantioselective Recognition of Various Chiral Amino Acids Based on a Dummy Template Strategy.
Anal Chem
January 2025
Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
Designing single-template molecularly imprinted chiral sensors for the enantioselective recognition of various chiral amino acids (AAs) is of great importance for chiral analysis. Here, a dummy template-based chiral sensor is developed by using l-alanine (l-Ala) as the dummy template and poly(-phenylenediamine) as the imprinting layer, which can be used for the enantioselective recognition of various chiral AAs such as Ala, tryptophan (Trp), tyrosine (Tyr), cysteine (Cys), and arginine (Arg). Compared with conventional single-template molecularly imprinted chiral sensors, the designed single-template chiral sensor shows great universality for the recognition of chiral AAs since all chiral AAs possess an Ala-analogous segment.
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