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Reframing Immune-Mediated Inflammatory Diseases. Reply.
N Engl J Med
November 2021
Deutsches Zentrum Immuntherapie, Friedrich Alexander University Erlangen-Nuremberg, Erlangen, Germany
Reframing Immune-Mediated Inflammatory Diseases.
N Engl J Med
November 2021
Setif-1 University, Setif, Algeria
Reframing Immune-Mediated Inflammatory Diseases through Signature Cytokine Hubs.
N Engl J Med
August 2021
From the Departments of Medicine 3 (G.S.) and Medicine 1 (M.F.N.) and Deutsches Zentrum Immuntherapie (G.S., M.F.N.), Friedrich Alexander University Erlangen-Nuremberg and Universitätsklinikum Erlangen, Erlangen, Germany; and the College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom (I.B.M.).
Hygiene Hypothesis in Asthma Development: Is Hygiene to Blame?
Arch Med Res
November 2017
Department of Physiology and Pharmacology,; Department of Paediatrics, University of Calgary, Canada. Electronic address:
Industrialized countries have registered epidemic rates on allergic diseases, such as hay fever, asthma, eczema, and food allergies. The Hygiene Hypothesis was born from work made by Dr. David Strachan, who observed that younger siblings were less susceptible to eczema and asthma, and proposed that this was a result of increased transmission of infectious agents via unhygienic practices within a household.
View Article and Find Full Text PDFAn immunologic portrait of cancer.
J Transl Med
August 2011
Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and Trans-NIH Center for Human Immunology (CHI), National Institutes of Health, Bethesda, Maryland 20892, USA.
The advent of high-throughput technology challenges the traditional histopathological classification of cancer, and proposes new taxonomies derived from global transcriptional patterns. Although most of these molecular re-classifications did not endure the test of time, they provided bulk of new information that can reframe our understanding of human cancer biology. Here, we focus on an immunologic interpretation of cancer that segregates oncogenic processes independent from their tissue derivation into at least two categories of which one bears the footprints of immune activation.
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