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Evolutionary diversification and succession of soil huge phages in glacier foreland.
Microbiome
January 2025
Key Laboratory of Urban Environment and Health, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, 361021, China.
Background: Huge phages (genome size ≥ 200 kb) have been detected in diverse habitats worldwide, infecting a variety of prokaryotes. However, their evolution and adaptation strategy in soils remain poorly understood due to the scarcity of soil-derived genomes.
Results: Here, we conduct a size-fractioned (< 0.
Comprehensive analysis of protein post-translational modifications reveals PTPN2-STAT1-AOX axis-mediated tumor progression in hepatocellular carcinomas.
Transl Oncol
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Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Clinical Research Center of Hepatobiliary and Pancreatic Diseases, Zhejiang Province, China; Zhejiang University Cancer Center, Hangzhou, China. Electronic address:
Hepatocellular carcinoma (HCC) is a common malignant tumor. Although the proteomics of HCC is well studied, the landscape of post-translational modifications (PTMs) in HCC is poorly understood. The PTMs themselves and their crosstalk might be deeply involved in HCC development and progression.
View Article and Find Full Text PDFExploring extracellular RNA as drivers of chemotherapy resistance in cancer.
Mol Biol Rep
January 2025
Centre for Research Impact & Outcome-Chitkara College of Pharmacy, Chitkara University, Punjab, India.
Chemotherapy resistance (CR) represents one of the most important barriers to effective oncological therapy and often leads to ineffective intervention and unfavorable clinical prognosis. Emerging studies have emphasized the vital significance of extracellular RNA (exRNA) in influencing CR. This thorough assessment intends to explore the multifaceted contributions of exRNA, such as exosomal RNA, microRNAs, long non-coding RNAs, and circular RNAs, to CR in cancer.
View Article and Find Full Text PDFThe influence of land surface temperature on Ghana's climate variability and implications for sustainable development.
Sci Rep
January 2025
Department of Geography and Spatial Information Techniques, School of Civil and Environmental Engineering and Geography Science, Ningbo University, Ningbo, 315211, China.
Climate change poses significant global challenges, especially in the West African sub-region, with high temperature and precipitation patterns variability, threatening socio-economic stability and ecosystem health. While global factors such as greenhouse gases and oceanic circulations shape regional climates, this study focuses on the understudied role of local climatic variables in influencing near-surface air temperature (NST) in Ghana from 1981 to 2020. Based on ground observations, our findings reveal significant correlations between land surface temperature (LST) and NST before and after the identified breakpoint year of 2001.
View Article and Find Full Text PDFRapid urbanization decelerates regional net anthropogenic phosphorus input: Evidence from the Chengdu-Chongqing urban agglomeration in China.
J Environ Manage
January 2025
Beijing Key Lab for Source Control Technology of Water Pollution, College of Environmental Science and Engineering, Beijing Forestry University, Beijing, 100083, China; Engineering Research Center for Water Pollution Source Control & Eco-remediation, College of Environmental Science and Engineering, Beijing Forestry University, Beijing, 100083, China. Electronic address:
Mitigating the pressure of regional phosphorus (P) inputs driven by human activities is essential for the prevention and control of non-point source pollution as well as for effective environmental management. This study emploied the net anthropogenic phosphorus input (NAPI) model and the coupling coordination degree model (CCDM) to quantitatively analyze the spatiotemporal evolution of phosphorus inputs and urbanization levels in the Chengdu-Chongqing urban agglomeration (CCUA) in Southwest China from 2011 to 2022. By integrating urbanization, socioeconomic and land use data, we identified key driving factors and specific indicators influencing changes in regional phosphorus inputs and their components.
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