Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic development. In this study, we confirmed that the C-terminus of BRMS1 is critical for metastasis suppression and hypothesized that critical protein interactions in this region would explain its function. Phosphorylation status at S237 regulates BRMS1 protein interactions related to a variety of biological processes, phenotypes [cell cycle (e.g., CDKN2A), DNA repair (e.g., BRCA1)], and metastasis [(e.g., TCF2 and POLE2)]. Presence of S237 also directly decreased MDA-MB-231 breast carcinoma migration in vitro and metastases in vivo. The results add significantly to our understanding of how BRMS1 interactions with Sin3/HDAC complexes regulate metastasis and expand insights into BRMS1's molecular role, as they demonstrate BRMS1 C-terminus involvement in distinct protein-protein interactions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8598058 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0259128 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Exploring the prognostic value of BRMS1 + microglia based on single-cell anoikis regulator patterns in the immunologic microenvironment of GBM.
J Neurooncol
October 2024
Department of Neurosurgery, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China.
Article Synopsis
- Anoikis is a type of programmed cell death that occurs when cells detach from their surrounding matrix, and resistance to this process is a key factor in cancer progression, especially in glioblastoma (GBM).
- The study used advanced techniques like single-cell RNA sequencing and co-culture experiments to analyze the tumor microenvironment (TME) in GBM, focusing on specific cell clusters and their gene signatures associated with anoikis.
- Findings revealed that certain immune cells in the TME, particularly BRMS1 + microglia, play a significant role in regulating tumor cell behaviors such as invasion and resistance to therapy, indicating potential targets for therapeutic interventions.
Perturbation of BRMS1 interactome reveals pathways that impact metastasis.
PLoS One
July 2024
Department of Cancer Biology, The Kansas University Medical Center, Kansas City, KS, United States of America.
Breast Cancer Metastasis Suppressor 1 (BRMS1) expression is associated with longer patient survival in multiple cancer types. Understanding BRMS1 functionality will provide insights into both mechanism of action and will enhance potential therapeutic development. In this study, we confirmed that the C-terminus of BRMS1 is critical for metastasis suppression and hypothesized that critical protein interactions in this region would explain its function.
View Article and Find Full Text PDFBRMS1: a multifunctional signaling molecule in metastasis.
Cancer Metastasis Rev
September 2020
Department of Cancer Biology, The Kansas University Medical Center, 3901 Rainbow Blvd., Kansas City, KS, 66160, USA.
Despite high mortality rates, molecular understanding of metastasis remains limited. It can be regulated by both pro- and anti-metastasis genes. The metastasis suppressor, breast cancer metastasis suppressor 1 (BRMS1), has been positively correlated with patient outcomes, but molecular functions are still being characterized.
View Article and Find Full Text PDFConcise approach for screening long non-coding RNAs functionally linked to human breast cancer associated genes.
Exp Mol Pathol
June 2019
Department of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, School of Veterinary Medicine, Seoul National University, Seoul, South Korea. Electronic address:
Cancer research studies using next-generation sequencing have revealed a number of genes of which aberrant expression is associated with various cancers. Recently, long non-coding RNA (lncRNA) has been highlighted due to its tissue-specific expression and cell cancerization functions, such as the regulation of key tumor suppressors. In this study, we suggest a very efficient approach to survey lncRNAs putatively associated with breast cancer.
View Article and Find Full Text PDFERα Mediates Estrogen-Induced Expression of the Breast Cancer Metastasis Suppressor Gene BRMS1.
Int J Mol Sci
January 2016
Department of Biological Sciences, Texas Tech University, 2901 Main St. Suite 108, Lubbock, TX 79409, USA.
Recently, estrogen has been reported as putatively inhibiting cancer cell invasion and motility. This information is in direct contrast to the paradigm of estrogen as a tumor promoter. However, data suggests that the effects of estrogen are modulated by the receptor isoform with which it interacts.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!