Radioactivity of the histamine-induced paw edema was measured after intravenous injection of 67Ga-citrate in anesthetized rats. The radioactivity was fluctuated almost parallel with the edema rate following subcutaneous injection of histamine. Both the radioactivity and the edema rate were almost equally reduced by pretreatment with chlorpheniramine, an antihistaminic agent. There was a good correlation between the edema rate and the radioactivity. These results suggest that 67Ga-citrate is useful for the pharmacological study of antiinflammatory drugs, or is available for measuring the vascular permeability.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.3769/radioisotopes.36.6_261 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Exploring the safety and feasibility of intracameral Aprokam® (cefuroxime sodium) in pediatric cataract surgery.
Int Ophthalmol
January 2025
Cleveland Clinic Abu Dhabi, Eye Institute, Abu Dhabi, United Arab Emirates.
Purpose: To describe the safety and assess the feasibility of using intracameral cefuroxime sodium (Aprokam®) during congenital cataract surgery as a preventive measure for endophthalmitis.
Design: Monocentric, prospective, observational pilot study.
Setting: San Giuseppe Hospital, University of Milan, Milan, Italy.
Auricular Mucormycosis: Comprehensive Literature Review.
Ear Nose Throat J
January 2025
Department of Otorhinolaryngology, Al Mouwasat University Hospital, Damascus University, Damascus, Syria.
Auricular mucormycosis is an exceptionally rare and aggressive fungal infection primarily affecting immunocompromised individuals, particularly those with poorly controlled diabetes. This report presents the case of a 54-year-old diabetic woman with isolated auricular mucormycosis and facial nerve palsy. The patient developed right auricular edema, necrosis, and severe pain, progressing over 10 days, with no history of trauma.
View Article and Find Full Text PDFFluconazole Induces Cardiovascular Toxicity in Zebrafish by Promoting Oxidative Stress, Apoptosis, and Disruption of Key Developmental Genes.
Chem Biol Interact
January 2025
Department of Orthopedics, The Affiliated Wuxi Clinical College of Nantong University, Jiangsu, 214000, China. Electronic address:
This study systematically evaluated the toxic effects of fluconazole on the cardiovascular development of zebrafish. Zebrafish embryos were treated with different concentrations of fluconazole (200, 400, and 800 μg/ml) to observe its impact on heart development, reactive oxygen species (ROS) generation, apoptosis, and hemoglobin production. The results showed that as the concentration of fluconazole increased, significant changes in zebrafish heart structure were observed, along with a notable reduction in heart rate.
View Article and Find Full Text PDFRelevance of superoxide dismutase type 1 to lipoid pneumonia: the first retrospective case-control study.
Respir Res
January 2025
National Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Chinese Academy of Medical Sciences, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, P. R. China.
Background: Lipoid pneumonia (LP) is a rare disease caused by the accumulation of lipids and lipid-laden macrophages in the alveoli inducing damage. LP is difficult to differentiate from other similar diseases without pathological evidence, such as upper respiratory tract infection (URTI), pneumonia, cryptogenic organizing pneumonia (COP), pulmonary alveolar proteinosis (PAP), lung mucinous adenocarcinoma and pulmonary edema. Given the high misdiagnosis rate and limited statistical clinical and treatment data, there is an urgent need for novel indicators of LP.
View Article and Find Full Text PDFEarly-Onset Seizures After Orthotopic Liver Transplantation: A Single-Center Retrospective Study.
Transplant Proc
January 2025
Neurology Service, Department of Diagnostic and Therapeutic Services, Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (ISMETT) - Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), University of Pittsburgh Medical Center (UPMC), Palermo, Italy.
Background: After encephalopathy, epileptic seizures (ES) are the second most common neurologic complication after orthotopic liver transplantation (OLT) and may announce a disabling/fatal neurologic disease.
Methods: In this retrospective study, we collected clinical information from patients who underwent OLT at our institution and analyzed outcomes and potential risk factors for developing ES after OLT.
Results: Fourteen of our 376 patients (3.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!