We report sequential metal catalysis towards indolocarbazole glycosides. The signature event is highlighted by i) Pd -catalyzed addition of indolocarbazole to alkoxyallene combined with ring-closing-metathesis; ii) Ru-catalyzed chemoselective olefin migration; iii) Pd -catalyzed oxidative cyclization to build the bicyclic core structure of the target compounds. This approach gave access to both natural pyranose- and non-natural septanose glycosides. A short formal synthesis of 7-oxostaurosporine was achieved via this strategy.
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| http://dx.doi.org/10.1002/anie.202112524 | DOI Listing |
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