AI Article Synopsis
- The study aims to identify the characteristics of pediatric patients with familial Mediterranean fever (FMF) who also have ocular inflammatory diseases (OID).
- Five cases from a cohort of 512 pediatric FMF patients showed OIDs, including various forms of uveitis and optic neuritis, with some being the first cases documented in FMF literature.
- The findings suggest a higher occurrence of OIDs in FMF patients, particularly those with the M694V mutation, indicating a potential link between FMF and the development of ocular inflammation.
Article Abstract
Purpose: To describe the characteristics of patients with familial Mediterranean fever (FMF) with concurrent ocular inflammatory disease (OID) and to analyze possible relations between them.
Methods: Clinical data were extracted from electronic medical records. Additionally, the medical literature on OIDs reported in patients with FMF was reviewed.
Results: Among 512 pediatric patients with FMF, five cases were found to have OIDs: bilateral anterior chronic uveitis, bilateral panuveitis, recurrent optic neuritis (RON), recurrent orbital myositis (ROM), and acquired Brown's syndrome. The first cases of ROM and acquired Brown's syndrome in FMF have been described in the literature. All cases presented with early-onset typical FMF attacks, carried at least one M694V mutation, and experienced OID while on colchicine.
Conclusion: Increased frequency of OIDs in FMF as per the pediatric population and relapsing and chronic course of OIDs occasionally with concurrent FMF attacks suggest that this inflammatory syndrome, especially those carrying M694V mutations, may be a predisposing factor for OIDs.
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| http://dx.doi.org/10.1007/s10792-021-02111-6 | DOI Listing |
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