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| http://dx.doi.org/10.1016/j.medcle.2021.05.006 | DOI Listing |
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Familial Early-Onset Alzheimer's Caused by Novel Genetic Variant and APP Duplication: A Cross-Sectional Study.
Curr Alzheimer Res
January 2023
Institute of Human Genetics, Galilee Medical Center, Nahariya, Israel.
Background: The clinical characteristics of symptomatic and asymptomatic carriers of early- onset autosomal dominant Alzheimer's (EOADAD) due to a yet-undescribed chromosomal rearrangement may add to the available body of knowledge about Alzheimer's disease and may enlighten novel and modifier genes. We report the clinical and genetic characteristics of asymptomatic and symptomatic individuals carrying a novel APP duplication rearrangement.
Methods: Individuals belonging to a seven-generation pedigree with familial cognitive decline or intracerebral hemorrhages were recruited.
Gut-oriented interventions in patients with multiple sclerosis: fact or fiction?
Eur Rev Med Pharmacol Sci
February 2022
Neurology Unit, Department of Neurology, MS Center, Ospedale San Raffaele, Milan, Italy.
Objective: Multiple sclerosis (MS) is a chronic, inflammatory, demyelinating, disimmune disease of the central nervous system whose etiology and pathogenesis remain poorly understood, due to its complex and multifactorial nature. Evidence of a bidirectional connection linking the gut microbiome with the intestinal barrier and the immune system (the gut-brain axis) may have implications for the pathogenesis of inflammatory demyelinating diseases such as MS. This narrative review summarizes the evidence for the gut-brain axis involvement in the pathogenesis of MS and examines the role of gut-oriented interventions in MS.
View Article and Find Full Text PDFDisimmune encephalopathy with onconeuronal antibodies in SARS-CoV-2 infected patients.
Med Clin (Engl Ed)
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Servicio de Neurología, Hospital Universitario de Getafe, Getafe, Madrid, Spain.
Disimmune encephalopathy with onconeuronal antibodies in SARS-CoV-2 infected patients.
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Servicio de Neurología, Hospital Universitario de Getafe, Getafe, Madrid, España.
[Organic troubles with psychiatric symptoms: What is the appropriate childhood and adolescence psychiatric care? Reflections on disimmune encephalitis cases].
Arch Pediatr
May 2017
Unité de psychiatrie de l'enfant et de l'adolescent, CHU, 49933 Angers cedex 9, France. Electronic address:
Organic mental disorders are different and further revealed by increasingly advanced research. They are nevertheless misunderstood, without consensus, and raise clinical, diagnostic, and therapeutic questions. These disorders require effective collaboration between practitioners such as pediatricians and child psychiatrists.
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