Background: The features and prognosis of adenosquamous carcinoma (ASC) in oral and maxillofacial region have not thoroughly investigated, the purpose of this study is to describe clinicopathologic characteristics, treatment, and prognostic factors of this disease.
Methods: The data of 276 patients diagnosed with ASC in oral and maxillofacial region between 1975 and 2016 were collected from the Surveillance, Epidemiology, and End Results (SEER) database. The prognostic factors influencing overall survival (OS) and disease-specific survival (DSS) were identified by the Kaplan-Meier analysis and Cox regression analysis. The nomograms for OS and DSS were constructed to predict the prognosis of these patients.
Results: Of 276 included patients, 62.7% were male and 37.3% were female, with an average age at diagnosis of 63.5 years. The most common primary site is oral cavity (170/276), followed by salivary gland (106/276). The 3-, and 5-year OS of patients with ASC in oral and maxillofacial region were 49.0% and 38.9%, while the 3-, and 5-year DSS were 67.7%, and 60.4%, respectively. Patients who underwent surgery had longer OS (mOS: 58 m vs. 8 m) and DSS (mDSS: 193 m vs. 18 m) than those who did not. Age, AJCC-T/N/M category as well as surgery were independently associated with OS. Advanced T stage, distant metastases, and surgery were independent factors for DSS. The prognostic nomograms for OS and DSS were constructed, and the C-indexes were 0.71 (95% CI 0.66-0.76) and 0.76 (95% CI 0.67-0.85), respectively.
Conclusion: Surgery was the favorable prognostic factor for both OS and DSS among patients with ASC in oral and maxillofacial region.
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