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Transcriptome Analysis of Intracellular Amastigotes of Clinical Lines from Therapeutic Failure Patients after Infection of Human Macrophages.
Microorganisms
June 2022
Instituto de Parasitología y Biomedicina "López-Neyra", IPBLN-CSIC, Parque Tecnológico de Ciencias de la Salud, Avda. del Conocimiento 17, Armilla, 18016 Granada, Spain.
Leishmaniasis is considered to be one of the most neglected tropical diseases affecting humans and animals around the world. Due to the absence of an effective vaccine, current treatment is based on chemotherapy. However, the continuous appearance of drug resistance and therapeutic failure (TF) lead to an early obsolescence of treatments.
View Article and Find Full Text PDFHolistic fine-grained global glomerulosclerosis characterization: from detection to unbalanced classification.
J Med Imaging (Bellingham)
January 2022
Vanderbilt University, Department of Electrical Engineering and Computer Science, Nashville, United States.
Recent studies have demonstrated the diagnostic and prognostic values of global glomerulosclerosis (GGS) in IgA nephropathy, aging, and end-stage renal disease. However, the fine-grained quantitative analysis of multiple GGS subtypes (e.g.
View Article and Find Full Text PDFDifferential Obsolescence and Strategic Flexibility.
HERD
October 2021
College of Architecture, Texas A&M University.
Focal segmental glomerulosclerosis, excluding atypical lesion, is a predictor of renal outcome in patients with membranous nephropathy: a retrospective analysis of 716 cases.
BMC Nephrol
August 2019
Department of Nephrology, The People's Hospital of Guangxi Zhuang Autonomous Region, 6 Taoyuan Road, Qingxiu District, Nanning, 530000, China.
Background: Focal segmental lesions (FSLs) are not uncommon in idiopathic membranous nephropathy (IMN). The reported percentage of IMN patients with focal segmental glomerulosclerosis (FSGS) lesions varies widely between studies. The objective of this study was to differentiate atypical FSL (aFSL) from typical FSGS in IMN and to analyse the clinicopathological predictors of primary outcome of IMN patients.
View Article and Find Full Text PDFVestigial tooth anatomy and tusk nomenclature for monodon monoceros.
Anat Rec (Hoboken)
June 2012
Department of Restorative Dentistry and Biomaterial Sciences, Harvard School of Dental Medicine, Boston, Massachusetts, USA.
Narwhal tusks, although well described and characterized within publications, are clouded by contradictory references, which refer to them as both incisors and canines. Vestigial teeth are briefly mentioned in the scientific literature with limited descriptions and no image renderings. This study first examines narwhal maxillary osteoanatomy to determine whether the erupted tusks are best described as incisiform or caniniform teeth.
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