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Herein are reported ligand-coupling reactions of Grignard reagents with pyridylsulfonium salts. The method has wide functional group tolerance and enables the formation of bis-heterocycle linkages, including 2,4'-, 2,3'-, and 2,2'-bipyridines, as well as pyridines linked to pyrimidines, pyrazines, isoxazoles, and benzothiophenes. The methodology was successfully applied to the synthesis of the natural products caerulomycin A and E.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8650099 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.1c03379 | DOI Listing |
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