Apathy and fatigue have distinct aetiologies, yet can manifest in phenotypically similar ways. In particular, each can give rise to diminished goal-directed behaviour, which is often cited as a key characteristic of both traits. An important issue therefore is whether currently available approaches are capable of distinguishing between them. Here, we examined the relationship between commonly administered inventories of apathy and fatigue, and a measure of goal-directed activity that assesses the motivation to engage in effortful behaviour. 103 healthy adults completed self-report inventories on apathy (the Dimensional Apathy Scale), and fatigue (the Multidimensional Fatigue Inventory, and/or Modified Fatigue Impact Scale). In addition, all participants performed an effort discounting task, in which they made choices about their willingness to engage in physically effortful activity. Importantly, self-report ratings of apathy and fatigue were strongly correlated, suggesting that these inventories were insensitive to the fundamental differences between the two traits. Furthermore, greater effort discounting was strongly associated with higher ratings across all inventories, suggesting that a common feature of both traits is a lower motivation to engage in effortful behaviour. These results have significant implications for the assessment of both apathy and fatigue, particularly in clinical groups in which they commonly co-exist.
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http://dx.doi.org/10.1038/s41598-021-01287-2 | DOI Listing |
J Clin Neurol
January 2025
Department of Neurology, Gyeongsang National University Hospital, Jinju, Korea.
Background And Purpose: Parkinson's disease (PD) significantly impacts the quality of life via both motor and nonmotor symptoms. Exercise is a valuable nonpharmacological intervention that can alleviate PD symptoms and slow disease progression. Understanding the factors that motivate and restrict exercise in PD patients is essential for promoting engagement.
View Article and Find Full Text PDFZhongguo Zhong Yao Za Zhi
September 2024
Amway (Shanghai) Technology Development Co., Ltd. Shanghai 201203, China.
Tongkat Ali(Eurycoma longifolia Jack.) is a medicinal plant of Simaroubaceae in Southeast Asia, with centuries of medicinal history. Rich clinical and pharmacological research results have been attained for this plant, which demonstrates diverse and definite effects and high safety, showcasing advantages and broad market prospects to be introduced as a new medicinal plant.
View Article and Find Full Text PDFClin Park Relat Disord
November 2024
Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, USA.
Background: Fatigue is a prevalent yet under-recognized non-motor symptom (NMS) of Parkinson's disease (PD), significantly impacting patients' quality of life. Despite its clinical importance, the relationship between fatigue and other motor and non-motor symptoms remains poorly understood. Its frequent co-occurrence with other NMS further complicates both diagnosis and management, often leading to underdiagnosis and suboptimal treatment.
View Article and Find Full Text PDFJ Bodyw Mov Ther
October 2024
Department of Psychiatry, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. Electronic address:
Introduction: Freezing of gait (FOG) is a debilitating episodic gait disorder that significantly reduces the quality of life (QoL) in patients with Parkinson's disease (PD). Diagnosing and treating FOG remains a major medical challenge. This study aimed to assess the correlation between FOG and both motor and non-motor clinical characteristics in patients with PD.
View Article and Find Full Text PDFNeurohospitalist
September 2024
Department of Neurology, University Hospital "12 de Octubre", Madrid, Spain.
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