AI Article Synopsis
- The study aimed to assess ART outcomes for infertile men with balanced chromosomal rearrangements or Y-chromosome microdeletions and compare them to a control group, focusing on clinical pregnancy rates.
- In a retrospective case-control analysis at two university hospitals, results showed a clinical pregnancy rate of 28% for men with chromosomal rearrangements and 43% for those with Y-chromosome microdeletions, compared to 24% in the control group, which was not significantly different.
- The findings suggest that these genetic issues do not significantly impact clinical pregnancy rates in conventional ART, but further studies are needed for validation.
Article Abstract
The aim of this study was to evaluate the ART outcomes for infertile males carrying a balanced structural chromosomal rearrangement or a Y-chromosome microdeletion, and to compare the results with a control group. The primary outcome was the clinical pregnancy rate. A retrospective case-control study has been carried out in the ART departments of the university hospitals of Bordeaux and la Réunion. Results of karyotypes and Y-chromosome microdeletions analysis of infertile men with sperm concentration lower than 5 millions/mL have been extracted from the softwares Jfiv (Bordeaux) and MédiFirst (la Réunion). The clinical pregnancy rate for carriers of balanced chromosomal rearrangements and Y-chromosome microdeletions was 28% and 43% respectively. The clinical pregnancy rate for the controls was 24% (non-significant difference). According to this study, balanced chromosomal rearrangements and Y-chromosome microdeletions are not found to affect the clinical pregnancy rate in conventional ART. Further larger scale studies are required to confirm these results.
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| http://dx.doi.org/10.1684/abc.2021.1676 | DOI Listing |
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