Objectives: This study seeks to discover how the concentration of complement proteins, factors B and P are affected in HIV-associated PE.
Methods: This study included 72 pregnant women: 36 preeclamptic and 36 normotensive. Serum concentrations of factors B and P were measured using a Bioplex immunoassay.
Results: A significant decrease of factor B in the HIV+ compared to the HIV- group was noted. No significant difference across all groups for both analytes was observed.
Conclusion: Our results suggest the alternative pathway (AP) is inhibited by HIV evading immune detection. The AP is not excessively activated in PE during the third trimester.
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| http://dx.doi.org/10.1080/10641955.2021.2001819 | DOI Listing |
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