Using two-dimensional (2D) and three-dimensional (3D) kinetic simulations, we examine the impact of simulation dimensionality on the laser-driven electron acceleration and the emission of collimated γ-ray beams from hollow microchannel targets. We demonstrate that the dimensionality of the simulations considerably influences the results of electron acceleration and photon generation owing to the variation of laser phase velocity in different geometries. In a 3D simulation with a cylindrical geometry, the acceleration process of electrons terminates early due to the higher phase velocity of the propagating laser fields; in contrast, 2D simulations with planar geometry tend to have prolonged electron acceleration and thus produce much more energetic electrons. The photon beam generated in the 3D setup is found to be more diverged accompanied with a lower conversion efficiency. Our paper concludes that the 2D simulation can qualitatively reproduce the features in 3D simulation, but for quantitative evaluations and reliable predictions to facilitate experiment designs 3D modeling is strongly recommended.
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http://dx.doi.org/10.1103/PhysRevE.104.045206 | DOI Listing |
J Alzheimers Dis
January 2025
Department of Geriatrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Background: The amyloid cascade hypothesis still dominates in Alzheimer's disease (AD), and the acceleration of the clearance efficiency of amyloid-β (Aβ) has been always considered as an effective treatment option to slow the occurrence and progression of AD.
Objective: This study aims to explore the role of zkscan3 and its related pathways in AD of the microglia-mediated pathogenesis, and whether the combined effect of drugs can exert neuroprotective function.
Methods: N9 mouse microglia and HT-22 mouse hippocampal neurons were randomly divided into 6 groups, qRT-PCR technique was used to detect the gene expression level of zkscan3 and the genes related to lysosome generation and function.
J Hazard Mater
January 2025
Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China.
Sunlight irradiation of dissolved organic matter (DOM) in surface water results in the production of photochemically produced reactive intermediates (PPRIs). This process is inevitably influenced by co-existing metal ions in aquatic environments; However, the underlying mechanism remains unclear. In this study, the effect of co-existing copper ion (Cu) on PPRIs produced by irradiation of DOM was systematically investigated, because Cu is a typical redox transient cation and has strong affinity to DOM.
View Article and Find Full Text PDFSci Adv
January 2025
Department of Chemistry, Brown University, Providence, RI, USA.
Disulfide bonds are ubiquitous molecular motifs that influence the tertiary structure and biological functions of many proteins. Yet, it is well known that the disulfide bond is photolabile when exposed to ultraviolet C (UVC) radiation. The deep-UV-induced S─S bond fragmentation kinetics on very fast timescales are especially pivotal to fully understand the photostability and photodamage repair mechanisms in proteins.
View Article and Find Full Text PDFInorg Chem
January 2025
Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Molecular Sciences, Henan University, Kaifeng, Henan 475004, P. R. China.
Developing new photocatalysts for the selective oxidation of thioethers to high-value-added sulfoxides under low-oxygen mild conditions is a promising but challenging strategy. Here, a new polyoxometalate-based metal-organic framework (POMOF), , was successfully synthesized, wherein continuous π···π stacking interactions and direct coordination bonds not only strengthen the framework's stability but also accelerate electron transfer. A series of experiments and theoretical studies, including control experiments, kinetic studies, electrochemical spectroscopic analyses, and electron paramagnetic resonance, revealed the synergistic catalytic effect among Co(II) metal centers, BWO, and the photosensitizer TPT.
View Article and Find Full Text PDFJ Chem Phys
January 2025
Department of Physics, Wesleyan University, Middletown, Connecticut 06459, USA.
Phase change materials such as Ge2Sb2Te5 (GST) are ideal candidates for next-generation, non-volatile, solid-state memory due to the ability to retain binary data in the amorphous and crystal phases and rapidly transition between these phases to write/erase information. Thus, there is wide interest in using molecular modeling to study GST. Recently, a Gaussian Approximation Potential (GAP) was trained for GST to reproduce Density Functional Theory (DFT) energies and forces at a fraction of the computational cost [Zhou et al.
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