We report and discuss, by means of pore-scale numerical simulations, the possibility of achieving a directional-dependent two-phase flow behavior during the process of invasion of a viscous fluid into anisotropic porous media with controlled design. By customising the pore-scale morphology and heterogeneities with the adoption of anisotropic triangular pillars distributed with quenched disorder, we observe a substantially different invasion dynamics according to the direction of fluid injection relative to the medium orientation, that is depending if the triangular pillars have their apex oriented (flow aligned) or opposed (flow opposing) to the main flow direction. Three flow regimes can be observed: (i) for low values of the ratio between the macroscopic pressure drop and the characteristic pore-scale capillary threshold, i.e., for Δp_{0}/p_{c}≤1, the fluid invasion dynamics is strongly impeded and the viscous fluid is unable to reach the outlet of the medium, irrespective of the direction of injection; (ii) for intermediate values, 1<Δp_{0}/p_{c}≤2, the viscous fluid reaches the outlet only when the triangular pillars are flow-opposing oriented; (iii) for larger values, i.e., for Δp_{0}/p_{c}>2, the outlet is again reached irrespective of the direction of injection. The porous medium anisotropy induces a lower effective resistance when the pillars are flow-opposing oriented, suppressing front roughening and capillary fingering. We thus argue that the invasion process occurs as long as the pressure drop is larger then the macroscopic capillary pressure determined by the front roughness, which in the case of flow-opposing pillars is halved. We present a simple approximated model, based on Darcy's assumptions, that links the macroscopic effective permeability with the directional-dependent front roughening, to predict the asymmetric invasion dynamics. This peculiar behavior opens up the possibility of fabrication of porous capillary valves to control the flow along certain specific directions.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1103/PhysRevE.104.045103 | DOI Listing |
Phys Eng Sci Med
January 2025
Amrita School of Artificial Intelligence, Amrita Vishwa Vidyapeetham, Bangalore, India.
Parkinson Disease (PD) is a complex neurological disorder attributed by loss of neurons generating dopamine in the SN per compacta. Electroencephalogram (EEG) plays an important role in diagnosing PD as it offers a non-invasive continuous assessment of the disease progression and reflects these complex patterns. This study focuses on the non-linear analysis of resting state EEG signals in PD, with a gender-specific, brain region-specific, and EEG band-specific approach, utilizing recurrence plots (RPs) and machine learning (ML) algorithms for classification.
View Article and Find Full Text PDFInt J Med Robot
February 2025
Shenyang Jianzhu University, Shenyang, China.
Background: A surgical robot with force feedback can guarantee precise and gentle manipulation for endometrial repair, ensuring the effectiveness and safety of the manipulation. However, the design of force sensors for surgical robots is challenging due to the limited anatomical space and the requirement for continuous rotation.
Methods: This paper presents a novel force-sensing surgical instrument for endometrial repair, including an inner scraping instrument and an outer force sensing sheath.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. HPV-negative HNSCC, which arises in the upper airway mucosa, is particularly aggressive, with nearly half of patients succumbing to the disease within five years and limited response to immune checkpoint inhibitors compared to other cancers. There is a need to further explore the complex immune landscape in HPV-negative HNSCC to identify potential therapeutic targets.
View Article and Find Full Text PDFIn confluent cell monolayers, patterns of cell forces and motion are systematically altered near topological defects in cell shape. In turn, defects have been proposed to alter cell density, extrusion, and invasion, but it remains unclear how the defects form and how they affect cell forces and motion. Here, we studied +1/2 defects, and, in contrast to prior studies, we observed both tail-to-head and head-to-tail defect motion occurring at the same time in the same cell monolayer.
View Article and Find Full Text PDFNeurophotonics
January 2025
California Institute of Technology, Department of Electrical Engineering, Pasadena, California, United States.
Significance: Cerebral blood flow (CBF) and cerebral blood volume (CBV) are key metrics for regional cerebrovascular monitoring. Simultaneous, non-invasive measurement of CBF and CBV at different brain locations would advance cerebrovascular monitoring and pave the way for brain injury detection as current brain injury diagnostic methods are often constrained by high costs, limited sensitivity, and reliance on subjective symptom reporting.
Aim: We aim to develop a multi-channel non-invasive optical system for measuring CBF and CBV at different regions of the brain simultaneously with a cost-effective, reliable, and scalable system capable of detecting potential differences in CBF and CBV across different regions of the brain.
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!