AI Article Synopsis
- Piezo1 is a mechanosensitive ion channel that plays crucial roles in various bodily functions, including cardiovascular, lung, urinary, and immune systems.
- Although significant research has been conducted over the past decade to understand Piezo1's functions and characteristics, some aspects remain unclear, particularly in comparison to other ion channels.
- This review explores the signaling pathways triggered by mechanical stimulation of Piezo1 and discusses its downstream effects, which could lead to potential treatment targets for diseases associated with this ion channel.
Article Abstract
Piezo1 is a mechanosensitive ion channel with essential roles in cardiovascular, lung, urinary, and immune functions. Piezo1 is widely distributed in different tissues in the human body and its specific roles have been identified following a decade of research; however, not all are well understood. Many structural and functional characteristics of Piezo1 have been discovered and are known to differ greatly from the characteristics of other mechanosensitive ion channels. Understanding the mechanisms by which this ion channel functions may be useful in determining its physiological roles in various organ systems. This review provides insight into the signalling pathways activated by mechanical stimulation of Piezo1 in various organ systems and cell types. We discuss downstream targets of Piezo1 and the overall effects resulting from Piezo1 activation, which may provide insights into potential treatment targets for diseases involving this ion channel.
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| http://dx.doi.org/10.1111/brv.12814 | DOI Listing |
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