AI Article Synopsis
- Salivary duct carcinoma (SDC) is a dangerous type of salivary gland cancer with a variety of forms, including a rare variant called sarcomatoid SDC, which was the focus of this study.
- The research examined three patients with sarcomatoid SDC, analyzing their cancer characteristics and molecular profiles, revealing that the tumors had both invasive ductal carcinoma and sarcomatoid features.
- Key findings included that diagnostic markers like androgen receptor (AR) and epithelial membrane antigen (EMA) were consistent across different tumor areas, and that genetic changes in the sarcomatoid variant were similar to those in the typical variant of SDC, suggesting a shared pathology.
Article Abstract
Aims: Salivary duct carcinoma (SDC) is an aggressive salivary gland neoplasm with a poor prognosis. Morphologically, it has many variants including sarcomatoid SDC. We evaluated the morphological features, immunohistochemistry profile, and genomic alteration of the rare variant, sarcomatoid SDC.
Methods And Results: We evaluated the clinicopathological and molecular pathology for rare variant of sarcomatoid SDC. Among 102 SDC patients, three had sarcomatoid SDC. Review of clinicopathological features and immunohistochemistry and targeted exome sequencing was performed according to carcinomatous and sarcomatoid areas, respectively. The tumors were present in two submandibular glands and one parotid gland. In one case, a SDC arose in carcinoma ex pleomorphic adenoma. All consisted of a conventional invasive ductal carcinoma area and sarcomatoid features including spindle cells and multinucleated giant cells. AR and epithelial membrane antigen (EMA) were positive in both carcinoma and sarcomatoid areas. Cytokeratin AE1/AE3 were negative in all sarcomatoid areas. Targeted exome sequencing revealed multiple heterogeneous alterations including PIK3CA and TP53. Genomic alterations were nearly identical between typical carcinoma and sarcomatoid areas.
Conclusions: Clinicopathological features of sarcomatoid SDCs were not different from typical SDC, and genomic alteration according to subtypes was also similar to that of the conventional type. Androgen receptor (AR) expression is helpful in the diagnosis of SDC. The findings indicate that EMA and AR are useful in diagnosing sarcomatoid SDC when the tumor is composed of predominantly sarcomatoid components.
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| http://dx.doi.org/10.1016/j.prp.2021.153678 | DOI Listing |
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Article Synopsis
- Salivary duct carcinoma (SDC) is a dangerous type of salivary gland cancer with a variety of forms, including a rare variant called sarcomatoid SDC, which was the focus of this study.
- The research examined three patients with sarcomatoid SDC, analyzing their cancer characteristics and molecular profiles, revealing that the tumors had both invasive ductal carcinoma and sarcomatoid features.
- Key findings included that diagnostic markers like androgen receptor (AR) and epithelial membrane antigen (EMA) were consistent across different tumor areas, and that genetic changes in the sarcomatoid variant were similar to those in the typical variant of SDC, suggesting a shared pathology.
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