Transition metal ion-doped ferrites nanoparticles for bioimaging and cancer therapy.

Transl Oncol

CAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, Chinese Academy of Sciences, Cixi Institute of Biomedical Engineering, Ningbo Institute of Materials Technology and Engineering, Ningbo 315201, PR China; Advanced Energy Science and Technology Guangdong Laboratory, Huizhou 516000, PR China. Electronic address:

Published: January 2022

AI Article Synopsis

  • Magnetic nanoparticles (MNPs) are important in biomedicine due to their ability to be manipulated without invasive methods and their compatibility with biological systems.
  • Transition metal doping in ferrite enhances the magnetic properties of MNPs, making them more effective for various biomedical applications.
  • The review discusses key characteristics of MNPs, explores recent advancements in their use for bioimaging and tumor therapies, and highlights ongoing challenges and future research directions.

Article Abstract

Magnetic nanoparticles (MNPs) have been extensively researched and implemented in biomedicine for more than half a century due to their non-invasive nature, ease of temporal and spatial manipulation, and considerable biocompatibility. However, the complex magnetic behaviour of MNPs is influenced by several parameters (e.g., particle size, shape, composition, core-shell structure, etc.), among which the amount of transition metal doping plays an important factor. For this reason, the doping of ferrite with transition metals has been used as an effective strategy to precisely tailor MNPs to achieve satisfactory performance in biomedical applications. In this review, we first introduced the main properties of coordinated MNPs (including magnetic moment and saturated magnetisation) and provide a comprehensive overview of the mechanistic studies related to the doping of transition metal ions into ferrite to precisely modulate its magnetic properties. We also highlighted the potential mechanisms and recent advances in transition metal ion-doped MNPs (TMNPs) for bioimaging (magnetic resonance imaging and magnetic particle imaging) and tumour therapy (e.g., magneto-mechanical killing, magnetothermal therapy, and drug delivery). Finally, we summarised the current challenges and future trends of TMNPs in the biomedical field based on the latest advances by researchers.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8593663PMC
http://dx.doi.org/10.1016/j.tranon.2021.101264DOI Listing

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