AI Article Synopsis
- The study investigates the epidemiological characteristics and association rules of concurrent extrapulmonary tuberculosis (EPTB) cases in China, addressing a gap in previous research that focused only on single-site EPTB.
- Conducted from January 2011 to December 2017 on over 208,000 patients, the research found tuberculous pleurisy to be the most common lesion, and identified key association rules concerning different EPTB types based on gender and age.
- The findings highlight the prevalence of multiple EPTB types occurring together and emphasize the need for increased awareness for timely diagnosis and treatment in clinical settings.
Article Abstract
Aims: A high proportion of all patients with tuberculosis (TB) present with extrapulmonary TB (EPTB), including concurrent EPTB involving more than one extrapulmonary lesion site. However, previous reports only characterized lesions of single-site EPTB cases. This study aimed to investigate epidemiological characteristics and association rules of concurrent EPTB cases in China.
Methods: An observational multi-centre study of 208,214 patients with EPTB lesions was undertaken in China from January 2011 to December 2017. Multi-variable logistic regression analysis was used to identify associations between gender and concurrent EPTB, and age and concurrent EPTB. Association rules were analysed for significance using the Apriori algorithm.
Results: The most common EPTB lesion was tuberculous pleurisy (49.8%), followed by bronchial TB (14.8%) and tuberculous meningitis (7.6%). The most common type of concurrent EPTB was tuberculous pleurisy concurrent with tuberculous peritonitis (1.80%). In total, 22 association rules, including 20 strong association rules, were identified; among these, the highest confidence rates were found for tuberculous myelitis concurrent with tuberculous meningitis, and sacral TB concurrent with lumbar vertebral TB. The association rules of EPTB concurrent with other EPTB types were found to vary with gender and age. The confidence rate of tuberculous myelitis concurrent with tuberculous meningitis was higher in females (83.67%) than males, and was highest in patients aged 25-34 years (87.50%).
Conclusions: Many types of concurrent EPTB were found. Greater awareness of concurrent EPTB disease characteristics is needed to ensure timely clinical diagnosis and treatment of this disease.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijid.2021.11.019 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A retrospective study of extrapulmonary tuberculosis in the Khuzestan province of southwest Iran between 2002 and 2023.
BMC Infect Dis
December 2024
Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Worldwide, tuberculosis (TB) is among the most common causes of death. To our knowledge, there has been no study showing the prevalence of EPTB in Khuzestan province. Therefore, the objective of this research was to investigate the prevalence of EPTB in patients with or without pulmonary TB in different cities of Khuzestan province from 2002 to 2023.
View Article and Find Full Text PDFNavigating the Diagnostic Labyrinth of Scrofuloderma Orbit in Conjunction with Jungling's Disease.
J Maxillofac Oral Surg
December 2024
Department of Oral & Maxillofacial Surgery, Army Dental Centre (Research & Referral), Cantt-10, Delhi, India.
Tuberculosis (TB) manifests in various forms, including extrapulmonary tuberculosis (EPTB), which poses diagnostic dilemmas due to its wide-ranging clinical presentations. When TB affects the bones of the hands and feet, it can present a diagnostic labyrinth for clinicians. In such cases, the differential diagnosis may include Jungling's bone disease, adding complexity to the diagnostic process.
View Article and Find Full Text PDFTuberculous Otomastoiditis: A Diagnostic Dilemma.
Cureus
October 2024
Otolaryngology - Head and Neck Surgery, Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia, Kuantan, MYS.
Where tuberculous (TB) infection is prevalent, the diagnosis of TB otomastoiditis (TOM) should be considered in a chronically discharging ear that does not respond to standard medical treatment. We are reporting a case of TB otomastoiditis with an adjacent deep neck abscess in a healthy 18-year-old male. He presented with a five five-month history of right otorrhea with hearing loss and a concurrent right level two neck swelling, without any signs of acute infection.
View Article and Find Full Text PDFDiagnostic Performance of Unstimulated IFN-γ (IRISA-TB) for Pleural Tuberculosis: A Prospective Study in South Africa and India.
Open Forum Infect Dis
October 2024
Centre for Lung Infection and Immunity, Division of Pulmonology, Department of Medicine and University of Cape Town Lung Institute, Cape Town, South Africa.
Article Synopsis
- Tuberculous pleural effusion (TPE) is a common form of tuberculosis outside the lungs, but current diagnostic methods like Xpert Ultra are not very effective, with a sensitivity of around 30%.
- A study in South Africa and India tested a new quick diagnostic method called IRISA-TB, comparing it against other assays and examining biopsy samples for TB confirmation.
- Results showed IRISA-TB had significantly better sensitivity (81.8%) and negative predictive value than Xpert Ultra and also outperformed other methods, indicating it could be a more reliable diagnostic tool for TPE.
Epidemiology and Clinical Characteristics of Ocular Tuberculosis in the United States, 1993-2019.
Open Forum Infect Dis
September 2024
Division of Infectious Diseases, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Article Synopsis
- Research revealed a total of 1766 ocular tuberculosis (OTB) cases in the US from 1993 to 2019, making up 1.6% of all extrapulmonary tuberculosis (EPTB) cases, with a significant increase observed during the last decade.
- Patients with OTB were generally older, more likely to be US-born, and had higher rates of diabetes compared to those with other EPTB forms, while being less frequently HIV positive.
- OTB cases were often not lab confirmed, primarily relied on interferon gamma release assay tests for diagnosis, and highlighted the need for further research to improve understanding and treatment of OTB.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!